Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) (CAT#: NS-099CN)
The anti-Vap-1 antibody BTT-1002 is a chimeric antibody that recognizes a functional epitope of VAP-1.
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Figure 1 The results of VAP-1 binding activity of the chimeric antibodies.
The binding of the chimeric antibodies and an irrelevant control antibody (ctrAb) to Ax cells expressing human VAP-1 or mock control cells was analysed by flow cytometry. Results are expressed as percentage of maximal mean channel fluorescence (MCF);
Inhib
Figure 2 The inhibition of the lymphocyte binding by anti-VAP-1 antibodies.
The abilities of the murine and chimeric antibodies to block the binding of lymphocytes to HEV were analysed using an in vitro frozen section assay. Sections were treated with anti-VAP-1 antibodies or with negative control antibodies (irrelevant monoclonal antibody 3G6 or human immunoglobulin). Results of two experiments are presented with their standard errors.
FC
Figure 3 The results of flow cytometric analysis of antibody binding to human Fcj/RI.
B2KA cells expressing human FcγR\ on their surface were incubated with the mouse (A) and chimeric (B) anti-VAP-1 antibodies followed by appropriate detection reagents. A human lgG1 antibody was used as a positive control in B.
Figure 4 The serum concentrations after i.v. injection of chimeric anti-VAP-1 antibody, BTT-1002 (panel A) and murine anti-VAP-1 antibody (panel B);
FuncS
Figure 5 The clinical score of BTT-1002 treated (panel A) and placebo treated (panel B) animals.
FuncS
Figure 6 The survival of rhesus monkeys in the CIA study.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Human IgG
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- BTT-1002
- Applications
- ELISA, FC, IF, IHC, Inhib, FuncS
- Related Disease
- Chronic inflammatory diseases
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Inhibition, Functional Assay.
Target
- Alternative Names
- Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; HPAO; SSAO; VAP1; Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1); Placenta Copper Monamine Oxidase; EC 1.4.3
- Gene ID
- 8639
- UniProt ID
- Q16853
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3906z | Mouse Anti-AOC3 Recombinant Antibody (clone 40D3) | WB, ELISA, FC, IHC, IP | Mouse IgG2a, κ |
| HPAB-1627LY | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3) | ELISA | Mouse IgG |
| HPAB-1628LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10) | ELISA | Mouse IgG |
| HPAB-1629LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6) | ELISA | Mouse IgG |
| HPAB-0966-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0966-FY) | IF | Human IgG |
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For Research Use Only. Not For Clinical Use.
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