Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) (CAT#: NS-099CN)
The anti-Vap-1 antibody BTT-1002 is a chimeric antibody that recognizes a functional epitope of VAP-1.
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Figure 1 The results of VAP-1 binding activity of the chimeric antibodies.
The binding of the chimeric antibodies and an irrelevant control antibody (ctrAb) to Ax cells expressing human VAP-1 or mock control cells was analysed by flow cytometry. Results are expressed as percentage of maximal mean channel fluorescence (MCF);
Inhib
Figure 2 The inhibition of the lymphocyte binding by anti-VAP-1 antibodies.
The abilities of the murine and chimeric antibodies to block the binding of lymphocytes to HEV were analysed using an in vitro frozen section assay. Sections were treated with anti-VAP-1 antibodies or with negative control antibodies (irrelevant monoclonal antibody 3G6 or human immunoglobulin). Results of two experiments are presented with their standard errors.
FC
Figure 3 The results of flow cytometric analysis of antibody binding to human Fcj/RI.
B2KA cells expressing human FcγR\ on their surface were incubated with the mouse (A) and chimeric (B) anti-VAP-1 antibodies followed by appropriate detection reagents. A human lgG1 antibody was used as a positive control in B.
Figure 4 The serum concentrations after i.v. injection of chimeric anti-VAP-1 antibody, BTT-1002 (panel A) and murine anti-VAP-1 antibody (panel B);
FuncS
Figure 5 The clinical score of BTT-1002 treated (panel A) and placebo treated (panel B) animals.
FuncS
Figure 6 The survival of rhesus monkeys in the CIA study.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Human IgG
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- BTT-1002
- Applications
- ELISA, FC, IF, IHC, Inhib, FuncS
- Related Disease
- Chronic inflammatory diseases
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Inhibition, Functional Assay.
Target
- Alternative Names
- Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; HPAO; SSAO; VAP1; Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1); Placenta Copper Monamine Oxidase; EC 1.4.3
- Gene ID
- 8639
- UniProt ID
- Q16853
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3906z | Mouse Anti-AOC3 Recombinant Antibody (clone 40D3) | WB, ELISA, FC, IHC, IP | Mouse IgG2a, κ |
| HPAB-1627LY | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3) | ELISA | Mouse IgG |
| HPAB-1628LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10) | ELISA | Mouse IgG |
| HPAB-1629LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6) | ELISA | Mouse IgG |
| HPAB-0966-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0966-FY) | IF | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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