Anti-Human APP Recombinant Antibody (2B3) (CAT#: TAB-0847CLV)
The anti-APP antibody 2B3 specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.
Specific Inquiry
WB
Figure 1 Representative Western blot of MOG-G-UVW lysate (50μg) detected with either 2B3 or 2B12 at 2μg/ml on a 10% gel.
Both antibodies detected full length APP at 103KDa (±2.5 KDa) and a smaller protein at 56KDa (±0.6 KDa), which was most likely a thrombin cleavage fragment of APP.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
ELISA
Figure 2 Differential 2B3 and 2B12 recognition of sAPPα and sAPPβ as determined by indirect ELISA.
Data are expressed as a mean (± SEM) % of the standard antibody (6E10) at 0.1μg/ml. 2B12 recognised sAPPα and sAPPβ equally well, however, significantly more 2B3 bound to sAPPα than to sAPPβ.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
Specifications
- Immunogen
- Ka (spanning the β-secretase cleavage site in human APP)
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 2B3
- Applications
- WB, ELISA
- Related Disease
- Alzheimer's Disease
Applications
- Application Notes
- The APP antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-016 | Recombinant Anti-Human APP VHH Single Domain Antibody | CA, IP, IF, FuncS | Llama VHH |
| TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
| TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH) | ELISA, IHC | Single domain antibody |
| TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
| TAB-0022CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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