Anti-Human APP Recombinant Antibody (2B3)

Name: Anti-Human APP Recombinant Antibody (2B3)
SKU: TAB-0847CLV
Rating: 5 (1 reviews)

CAT#: TAB-0847CLV

The anti-APP antibody 2B3 specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.

Published Data Gene Expression

Figure 1 Representative Western blot of MOG-G-UVW lysate (50μg) detected with either 2B3 or 2B12 at 2μg/ml on a 10% gel.

Both antibodies detected full length APP at 103KDa (±2.5 KDa) and a smaller protein at 56KDa (±0.6 KDa), which was most likely a thrombin cleavage fragment of APP.

Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.

ELISA

Figure 2 Differential 2B3 and 2B12 recognition of sAPPα and sAPPβ as determined by indirect ELISA.

Data are expressed as a mean (± SEM) % of the standard antibody (6E10) at 0.1μg/ml. 2B12 recognised sAPPα and sAPPβ equally well, however, significantly more 2B3 bound to sAPPα than to sAPPβ.

Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Immunogen
Ka (spanning the β-secretase cleavage site in human APP)

Host Species
Mouse

Specificity
Human

Clone
2B3

Applications
WB, ELISA

Related Disease
Alzheimer's Disease

Applications

Application Notes
The APP antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay.

Target

Alternative Names
APP; Amyloid Beta; amyloid beta (A4) precursor protein

Gene ID
351

UniProt ID
P05067

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0847CLV.pdf

MSDS

MSDS - TAB-0847CLV.pdf

COA

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