Afuco™ Anti-Human AQP4 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-051CL
Anti-AQP4 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO, a study on antibody titre. Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5079/if_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_B_7_5.jpg
Normal Tissue
Figure 4 Lung
Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_3_4.jpg
Normal Tissue
Figure 5 Kidney
Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Neuromyelitis optica
Product Property
- Purity
- >95% by HPLC
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AQP4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0977CLV | Anti-Human AQP4 Recombinant Antibody (D15107) | ELISA, FuncS, WB, IF, FC | Chimeric antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0672MZ | Mouse Anti-AQP4 Recombinant Antibody (clone 4E3) | ELISA, IHC-Fr, IHC-P, IP, WB | Mouse IgG1 |
| MOB-086CQ | Mouse Anti-AQP4 Recombinant Antibody (clone CBLS-192) | ELISA, IHC-Fr, IHC-P, WB, IHC-FoFr | Mouse IgG3, κ |
| VS3-FY92 | Recombinant Mouse Anti-AQP4 Antibody (VS3-FY92) | WB, IHC, IF | Mouse IgG |
| VS4-WK34 | Mouse Anti-AQP4 Recombinant Antibody (VS4-WK34) | ELISA, WB, IHC, IF | Mouse IgG |
| VS3-XY3264 | Rabbit Anti-AQP4 Recombinant Antibody (clone R05-8C3) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0223 | Hi-Affi™ Rabbit Anti-AQP4 Recombinant Antibody (clone DS223AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC282 | Recombinant Anti-AQP4 Vesicular Antibody, EV Displayed (VS-0425-YC282) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY479 | Anti-AQP4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY480 | Anti-Mouse AQP4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY481 | Anti-Rat AQP4 Immunohistochemistry Kit | IHC |
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