Anti-Human AQP4 Recombinant Antibody (D15107)

CAT#: TAB-0977CLV

The anti-aquaporin-4 antibody D15107 is an chimeric antibody targeting human aquaporin-4, and can be used for treating the neuromyelitis optica.

Published Data Gene Expression
Figure 1 Binding of the mAbs to hAQP4 M23 expressed on the envelope of budded baculovirus. Figure 2 Binding of the mAbs to hAQP4 M23 expressed on the envelope of budded baculovirus. Figure 3 Binding of the mAbs to hAQP4 M23 expressed on the envelope of budded baculovirus. Figure 4 Binding of the mAbs to AQP4 expressed in stable CHO cell lines. Figure 5 Live imaging of binding of fluorescent-labelled mAbs to hAQP4‐M1 cells. Figure 6 Effect of mAbs on levels of AQP4 in hAQP4-M1 cells. Figure 7 Effect of mAbs on levels of AQP4 in hAQP4-M1 cells. Figure 8 Binding of chimeric mAbs to hAQP4 M23 expressed on the envelope of budded baculovirus. Figure 9 Cytoprotective effect of chimeric D15107 against CDC induced by NMO-IgG. Figure 10 Injection (i.p. or intra-cerebral) of chimeric D15107 into mice. Figure 11 Binding properties of four established monoclonal antibodies using flow cytometry. Figure 12 Effect of amino acid substitutions in the extracellular loops of hAQP4 on binding of monoclonal antibodies. Figure 13 The monoclonal antibodies have no effect on water permeability of AQP4. Figure 14 The monoclonal antibodies have no effect on water permeability of AQP4. Figure 15 Effect of treatment with monoclonal antibodies on the binding of NMO-IgG to cells expressing hAQP4. Figure 16 Monoclonal antibodies replace the binding of NMO-IgG on the cell expressing AQP4.
Figure 1 IF staining of human cell line U-251 MG Figure 2 IF staining of human cell line A-431 Figure 3 Cerebral cortex Figure 4 Lung Figure 5 Kidney Figure 6 RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1)

Specifications

  • Host Species
  • Human
  • Type
  • Chimeric antibody
  • Specificity
  • Human
  • Clone
  • D15107
  • Applications
  • ELISA, FuncS, WB, IF, FC
  • Related Disease
  • Neuromyelitis optica

Applications

  • Application Notes
  • The antibody was validated for ELISA, Functional Assay, Western Blot, Immunofluorescence, Flow Cytometry. For details, refer to Published Data.

Target

  • Alternative Names
  • AQP4; aquaporin 4; MIWC; HMIWC
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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