Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) (CAT#: TAB-224)
Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
Host: Human
Isotype: IgG1 - lambda
Applications: FC, IP, ELISA, Neut, FuncS, IF, WB
Specific Inquiry
Figure 1 Inhibition of Raxibacumab.
Survival was significantly longer in all raxibacumab groups, and a significant dose–response trend for survival at day 14 (P<0.001) was observed.
Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., ... & Lewis, M. (2009). Raxibacumab for the treatment of inhalational anthrax. New England journal of medicine, 361(2), 135-144.
Figure 2 Raxibacumab pharmacokinetics.
Plasma raxibacumab concentration-time profiles in rabbits administered 3 daily intragastric 50-mg/kg LVX doses in combination with a single i.v. 40-mg/kg raxibacumab dose. (Top) Linear scale; (bottom) semilogarithmic scale.
Migone, T. S., Bolmer, S., Zhong, J., Corey, A., Vasconcelos, D., Buccellato, M., & Meister, G. (2015). Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax. Antimicrobial agents and chemotherapy, 59(2), 1145-1151.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - lambda
- Specificity
- Tested positive against native B. anthracis antigen.
- Species Reactivity
- B. anthracis
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, WB
- Trade name
- abthrax
- CAS
- 565451-13-0
- Generic Name
- Raxibacumab
- ATC Code
- J06BB18
- MW
- 142.93 kDa
- Related Disease
- Anthrax inhalation
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- The B. anthracis PA antibody has been reported in applications of Inhib, PK.
Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).
Target
- Alternative Names
- Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen
Related Resources
Please refer to Raxibacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Raxibacumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Raxibacumab"
Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
See other products for "B. anthracis PA"
Single-domain Antibody
| CAT | Product Name | Application | Type |
| NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-97 | Recombinant Anti-B. anthracis PA Antibody | ELISA, IF, FuncS | IgG |
| MRO-513-MZ | Mouse Anti-B. anthracis PA Recombinant Antibody (clone 7825) | ELISA | Mouse IgG |
| HPAB-0780-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0780-CN) | ELISA, Neut | Mouse IgG1, κ |
| FAMAB-0048JF | Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C) | ELISA, Neut, IHC, FC | Human IgG |
| VS3-QX94 | Mouse Anti-B. anthracis PA Recombinant Antibody (clone 5C1-C8-H8) | ELISA | Mouse IgG2b |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| MHH-97-F(E) | Recombinant Human Anti-B. anthracis PA Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| HPAB-0780-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0780-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0781-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0781-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-1646-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1646-FY-S(P)) | ELISA | Human scFv |
| FAMAB-0333JF-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); Fab Fragment | ELISA, FuncS | Human Fab |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
| EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-1825-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 1C6); scFv Fragment | ELISA | Human scFv |
| HPAB-1826-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7); scFv Fragment | ELISA | Human scFv |
| HPAB-0747-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment | ELISA, Neut | Chimpanzee scFv |
| HPAB-0748-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W2); scFv Fragment | ELISA, WB, Neut, FuncS | Chimpanzee scFv |
| FAMAB-0048JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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