Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) (CAT#: TAB-224)

Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.

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  • Published Data
  • Datasheet
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Figure 1 Inhibition of Raxibacumab.

Survival was significantly longer in all raxibacumab groups, and a significant dose–response trend for survival at day 14 (P<0.001) was observed.

Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., ... & Lewis, M. (2009). Raxibacumab for the treatment of inhalational anthrax. New England journal of medicine, 361(2), 135-144.

Figure 2 Raxibacumab pharmacokinetics.

Plasma raxibacumab concentration-time profiles in rabbits administered 3 daily intragastric 50-mg/kg LVX doses in combination with a single i.v. 40-mg/kg raxibacumab dose. (Top) Linear scale; (bottom) semilogarithmic scale.

Migone, T. S., Bolmer, S., Zhong, J., Corey, A., Vasconcelos, D., Buccellato, M., & Meister, G. (2015). Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax. Antimicrobial agents and chemotherapy, 59(2), 1145-1151.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - lambda
  • Specificity
  • Tested positive against native B. anthracis antigen.
  • Species Reactivity
  • B. anthracis
  • Applications
  • FC, IP, ELISA, Neut, FuncS, IF, WB
  • Trade name
  • abthrax
  • CAS
  • 565451-13-0
  • Generic Name
  • Raxibacumab
  • ATC Code
  • J06BB18
  • MW
  • 142.93 kDa
  • Related Disease
  • Anthrax inhalation

Applications

  • Application Notes
  • The B. anthracis PA antibody has been reported in applications of Inhib, PK.
    Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).

Target

  • Alternative Names
  • Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Raxibacumab.

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Afuco™ Anti-B. anthracis PA ADCC Therapeutic Antibody (Raxibacumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.

See other products for "B. anthracis PA"


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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