Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) (CAT#: TAB-224)

Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.

Host: Human

Isotype: IgG1 - lambda

Applications: FC, IP, ELISA, Neut, FuncS, IF, WB


Specific Inquiry
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  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA

Figure 1 Inhibition of Raxibacumab.

Survival was significantly longer in all raxibacumab groups, and a significant dose–response trend for survival at day 14 (P<0.001) was observed.

Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., ... & Lewis, M. (2009). Raxibacumab for the treatment of inhalational anthrax. New England journal of medicine, 361(2), 135-144.

Figure 2 Raxibacumab pharmacokinetics.

Plasma raxibacumab concentration-time profiles in rabbits administered 3 daily intragastric 50-mg/kg LVX doses in combination with a single i.v. 40-mg/kg raxibacumab dose. (Top) Linear scale; (bottom) semilogarithmic scale.

Migone, T. S., Bolmer, S., Zhong, J., Corey, A., Vasconcelos, D., Buccellato, M., & Meister, G. (2015). Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax. Antimicrobial agents and chemotherapy, 59(2), 1145-1151.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - lambda
  • Specificity
  • Tested positive against native B. anthracis antigen.
  • Species Reactivity
  • B. anthracis
  • Applications
  • FC, IP, ELISA, Neut, FuncS, IF, WB
  • Trade name
  • abthrax
  • CAS
  • 565451-13-0
  • Generic Name
  • Raxibacumab
  • ATC Code
  • J06BB18
  • MW
  • 142.93 kDa
  • Related Disease
  • Anthrax inhalation

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Applications

  • Application Notes
  • The B. anthracis PA antibody has been reported in applications of Inhib, PK.
    Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).

Target

  • Alternative Names
  • Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen

Related Resources

  • Biosimilar Overview
Please refer to Raxibacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Raxibacumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Raxibacumab"

Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.

See other products for "B. anthracis PA"

Single-domain Antibody

CAT Product Name Application Type
NAB-194-VHH Recombinant Anti-B. anthracis PA VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH

Recombinant Antibody

CAT Product Name Application Type
MOB-97 Recombinant Anti-B. anthracis PA Antibody ELISA, IF, FuncS IgG
MRO-513-MZ Mouse Anti-B. anthracis PA Recombinant Antibody (clone 7825) ELISA Mouse IgG
HPAB-0780-CN Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0780-CN) ELISA, Neut Mouse IgG1, κ
FAMAB-0048JF Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C) ELISA, Neut, IHC, FC Human IgG
VS3-QX94 Mouse Anti-B. anthracis PA Recombinant Antibody (clone 5C1-C8-H8) ELISA Mouse IgG2b

Fab Fragment Antibody

CAT Product Name Application Type
MHH-97-F(E) Recombinant Human Anti-B. anthracis PA Antibody Fab Fragment ELISA, WB, FC, FuncS Fab
HPAB-0780-CN-F(E) Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0780-CN-F(E)) ELISA, Neut Mouse Fab
HPAB-0781-CN-F(E) Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0781-CN-F(E)) ELISA, Neut Mouse Fab
HPAB-1646-FY-S(P) Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1646-FY-S(P)) ELISA Human scFv
FAMAB-0333JF-F(E) Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); Fab Fragment ELISA, FuncS Human Fab

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0387LC Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) BL, ELISA IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-224 Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-440CQ Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1825-FY-F(E) Human Anti-B. anthracis PA Recombinant Antibody (clone 1C6); scFv Fragment ELISA Human scFv
HPAB-1826-FY-F(E) Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7); scFv Fragment ELISA Human scFv
HPAB-0747-YJ-S(P) Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment ELISA, Neut Chimpanzee scFv
HPAB-0748-YJ-S(P) Chimpanzee Anti-PA Recombinant Antibody (W2); scFv Fragment ELISA, WB, Neut, FuncS Chimpanzee scFv
FAMAB-0048JF-S(P) Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C); scFv Fragment WB, ELISA, FuncS Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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