Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) (CAT#: TAB-224)
Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - lambda
- Specificity
- Tested positive against native B. anthracis antigen.
- Species Reactivity
- B. anthracis
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, WB
- Trade name
- abthrax
- CAS
- 565451-13-0
- Generic Name
- Raxibacumab
- ATC Code
- J06BB18
- MW
- 142.93 kDa
- Related Disease
- Anthrax inhalation
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- The B. anthracis PA antibody has been reported in applications of Inhib, PK.
Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).
Target
- Alternative Names
- Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen
Related Resources
Please refer to Raxibacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Raxibacumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Raxibacumab"
Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-224)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. It is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
DrugMonitor™ Anti-Raxibacumab Antibody (VS-1224-YC984)Raxibacumab is a monoclonal antibody used alongside antibacterial regimens for treating inhalational anthrax caused by Bacillus anthracis and for preventive treatment when necessary. The DrugMonitor™ Anti-Raxibacumab Antibody (VS-1224-YC984) is an anti-drug antibody (ADA) against Raxibacumab. This drug-based antibody is raised in mice immunized with the Raxibacumab. The anti-Raxibacumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Raxibacumab in samples.
See other products for "B. anthracis PA"
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Single Domain Antibody Products
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
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