Human Anti-BMPR1A Recombinant Antibody (clone AbD1556) (CAT#: PABL-412)

Recombinant Human Antibody (AbD1556) is capable of binding to BMPR-IA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-BMPR-IA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-BMPR-IA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.


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FuncS

Figure 1 Functional epitopes of AbD1156, AbD1564 and BMP-2.

Figure 1 Functional epitopes of AbD1156, AbD1564 and BMP-2.

Mutational analysis of the BMPR-IA binding epitope and in vitro interaction analysis shows that the contribution of residues within the epitope to the binding energy correlate for binding to AbD1556 and BMP-2, whereasthe two Fab AbD1556 and AbD1564 clearly bind to BMPR-IA via a different mechanism.

Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).

FuncS

Figure 2 SPR analysis of BMPR-IA binding to BMP-2 and Fab proteins.

Figure 2 SPR analysis of BMPR-IA binding to BMP-2 and Fab proteins.

Sensorgram of the interaction of wild type BMPR-IA (red) and the BMPR-IA variant Q86A (blue) with AbD1556.

Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).


Specifications

  • Immunogen
  • Human bone morphogenetic protein receptor, type IA
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human IgG
  • Specificity
  • BMPR-IA
  • Species Reactivity
  • Human
  • Clone
  • AbD1556
  • Applications
  • FuncS

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Function Assay.

Target

  • Alternative Names
  • BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serinethreonine-protein kinase receptor R5

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone AbD1556"

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Recombinant Antibody

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-409 Human Anti-BMPR1A Recombinant Antibody (clone AbD1556); Fab Fragment Neut, WB Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-409 Human Anti-BMPR1A Recombinant Antibody (clone AbD1556); scFv Fragment Neut, WB Human scFv

Neutralizing Antibody

CAT Product Name Application Type
NEUT-068CQ Mouse Anti-BMPR1A Recombinant Antibody (clone CBL674) Neut, WB Mouse IgG1

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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