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  • Afuco™ Anti-Human BST2 ADCC Recombinant Antibody (XmAb 5592), ADCC Enhanced

Afuco™ Anti-Human BST2 ADCC Recombinant Antibody (XmAb 5592), ADCC Enhanced (CAT#: AFC-072CL)

Anti-BST2 ADCC Enhanced Antibody (XmAb 5592) is an ADCC enhanced antibody produced by our Afuco™ platform. XmAb5592, a humanized anti-HM1. 24 mAb with Fc-domain engineered to significantly enhance FcγR binding and associated immune effector functions. The clinical development of XmAb5592, both as a monotherapy and in combination with lenalidomide, to improve patient outcome of multiple myeloma (MM).


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Subcellular Location
Figure 1 IF staining of human cell line SiHa
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73472/1920_E3_7_cr5cc2b8004d589_selected.jpg
Normal Tissue
Figure 2 Adrenal gland
Figure 2 Adrenal gland
(High expression in adrenal gland)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_B_4_5_val_selected.jpg
Figure 3 Lymph node
Figure 3 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_9_8.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_B_9_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_9_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_6_6.jpg
Figure 8 Placenta
Figure 8 Placenta
(Decidual cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_1_7.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130303-BST2

Specifications

  • Host Species
  • Humanized
  • Derivation
  • Humanized
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Multiple Myeloma

Product Property

  • Purity
  • 90–95% (SDS-PAGE)
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

  • Alternative Names
  • BST2; bone marrow stromal cell antigen 2; CD317; TETHERI

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "BST2"

Recombinant Antibody

CAT Product Name Application Type
MOB-1680z Mouse Anti-BST2 Recombinant Antibody (clone 19H4) WB, ELISA, IHC Mouse IgG2b
MRO-0195-CN Rabbit Anti-BST2 Recombinant Antibody (clone JU11-93) WB, IHC, FC Rabbit IgG
FN-136CQ Rat Anti-BST2 Recombinant Antibody (clone JF05-1C2.4.1) Depletion Rat IgG2b
FN-202CQ Rat Anti-BST2 Recombinant Antibody (clone CBL-1335) FC, FuncS Rat IgG2b, κ
HPAB-N0026-YC Mouse Anti-BST2 Recombinant Antibody (clone 1C12C6) ELISA, WB, IHC Mouse IgG

Immunotoxin

CAT Product Name Application Type
AGTO-G002E Anti-BST2 immunotoxin (scFv)-PE Cytotoxicity assay, Function study

Humanized Antibody

CAT Product Name Application Type
TAB-1295CL Human Anti-BST2 Recombinant Antibody (TAB-1295CL) Cyt, FC Humanized IgG1
TAB-1298CL Anti-Human BST2 Recombinant Antibody ELISA Humanized antibody
TAB-1295CL-S(P) Human Anti-BST2 Recombinant Antibody; scFv Fragment (TAB-1295CL-S(P)) FC Humanized scFv
TAB-1295CL-F(E) Human Anti-BST2 Recombinant Antibody; Fab Fragment (TAB-1295CL-F(E)) FC Humanized Fab
TAB-1298CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment ELISA Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1297CL Chimeric Anti-Human BST2 Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-1297CL-S(P) Chimeric Anti-Human BST2 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-1297CL-F(E) Chimeric Anti-Human BST2 Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-1299CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment (2-1L) FC
TAB-1300CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment (6-26H) ELISA
TAB-1301CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment (9-16-1) FC
TAB-1302CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment (2-20J) FC
TAB-1303CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment (b-76-8) ELISA, FC, FuncS

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC143 PE-A*02:01/Human HM1.24 (KLQDASAEV) MHC Tetramer FCM
MHC-LC144 APC-A*02:01/Human HM1.24 (KLQDASAEV) MHC Tetramer FCM

Neutralizing Antibody

CAT Product Name Application Type
NEUT-072CQ Mouse Anti-BST2 Recombinant Antibody (clone 26F8) FC, FuncS, Neut Mouse IgG1, κ
NEUT-073CQ Rat Anti-Bst2 Recombinant Antibody (VMC170) Neut, FC, IF, IHC, IHC-Fr, IHC-P Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0390 Hi-Affi™ Rabbit Anti-BST2 Recombinant Antibody (clone DS390AB) WB, IHC, FC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-N0026-YC-S(P) Mouse Anti-BST2 Recombinant Antibody (clone 1C12C6); scFv Fragment ELISA, WB, IHC Mouse scFv
HPAB-1004-FY-F(E) Mouse Anti-BST2 Recombinant Antibody (clone 4LD); scFv Fragment FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-N0026-YC-F(E) Mouse Anti-BST2 Recombinant Antibody (clone 1C12C6); Fab Fragment ELISA, WB, IHC Mouse Fab
HPAB-1004-FY-S(P) Human Anti-BST2 Recombinant Antibody (clone 4LD); Fab Fragment FC Chimeric (mouse/human) Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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