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    Anti-BST2 immunotoxin (scFv)-PE (CAT#: AGTO-G002E)

    This immunotoxin was achieved by conjugating/fusing the Anti-BST2 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to malignant plasma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating multiple myeloma (MM).

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line SiHa
    Figure 1 IF staining of human cell line SiHa
    (Immunofluorescent staining of human cell line SiHa shows localization to the Golgi apparatus & vesicles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/73472/1920_E3_7_cr5cc2b8004d589_selected.jpg
    Normal Tissue
    Figure 2 Adrenal gland
    Figure 2 Adrenal gland
    (High expression in adrenal gland)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_B_4_5_val_selected.jpg
    Figure 3 Lymph node
    Figure 3 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_9_8.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_B_9_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_9_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_6_6.jpg
    Figure 8 Placenta
    Figure 8 Placenta
    (Decidual cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17060/39065_A_1_7.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
    Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130303-BST2

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Molecule Class
    • scFv-PE
    • Toxin Description
    • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • multiple myeloma (MM)

    Target

    • Alternative Names
    • BST2; bone marrow stromal cell antigen 2; CD317; TETHERIN; bone marrow stromal antigen 2; BST-2; NPC-A-7; HM1.24 antigen; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "BST2"

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    CAT Product Name Application Type
    TAB-1295CL Human Anti-BST2 Recombinant Antibody (TAB-1295CL) Cyt, FC Humanized IgG1
    TAB-1295CL-S(P) Human Anti-BST2 Recombinant Antibody; scFv Fragment (TAB-1295CL-S(P)) FC Humanized scFv
    TAB-1298CL-S(P) Anti-Human BST2 Recombinant Antibody scFv Fragment ELISA Humanized antibody
    TAB-1295CL-F(E) Human Anti-BST2 Recombinant Antibody; Fab Fragment (TAB-1295CL-F(E)) FC Humanized Fab
    TAB-1298CL-F(E) Anti-Human BST2 Recombinant Antibody Fab Fragment ELISA Humanized antibody

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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