Recombinant Anti-human BaX Intrabody [Tat]

Name: Recombinant Anti-human BaX Intrabody [Tat]
SKU: IAB-B001(T)
Rating: 5 (1 reviews)

CAT#: IAB-B001(T)

Recombinant anti-BaX intrabody in fusion with HIV Tat works within cells and specifically reacts with pro-apoptotic protein BaX, expressed in CHO cells. These intrabodies are useful drugs on their own as well as a means for identifying small compound drugs for degenerative diseases involving oxidative-stress-induced apoptosis.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_9_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_4_6.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087088-BAX

❮

❯

Specifications

Immunogen
human BCL2-associated X protein

Host Species
llama

Type
vhh-Tat

Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

Species Reactivity
human

Applications
Antibody assay: Western blot; Neutralization; Functional studies

Product Property

Purity
>95% by HPLC

Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Target

Alternative Names
BAX; BCL2-associated X protein; BCL2L4; apoptosis regulator BAX; bcl2-L-4; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega; bcl-2-like protein 4; BCL2-associated X protein omega

Gene ID
581

UniProt ID
Q07812

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for IAB-B001(T). Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Related Diseases

Breast Cancer

Endometrial Cancer

Gastric Cancer

Prostate Cancer

Throid Cancer

AGE-RAGE Signaling Pathway in Diabetic Complications

Amyotrophic Lateral Sclerosis

Related Signaling Pathways

p53 Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - IAB-B001(T).pdf

MSDS

MSDS - IAB-B001(T).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "BAX"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-101	Recombinant Anti-human BAX Antibody	ELISA, WB, IF, FuncS	IgG

CAT	Product Name	Application	Type
MOB-101-F(E)	Recombinant Anti-human BAX Antibody Fab Fragment	IP, FuncS	Fab

CAT	Product Name	Application	Type
MOB-101-S(P)	Recombinant Anti-human BAX Antibody scFv Fragment	ELISA, IF, FuncS	scFv

CAT	Product Name	Application	Type
NABL-074	Recombinant Anti-human BAX VHH Single Domain Antibody	WB, ELISA, IP, FuncS	Llama VHH

CAT	Product Name	Application	Type
IAB-B001(A)	Recombinant Anti-human BaX Intrabody [(D-Arg)₉]	ELISA, ICC, FuncS	vhh-(D-Arg)₉

CAT	Product Name	Application	Type
IAB-B001(G)	Recombinant Anti-human BaX Intrabody [+36GFP]	PCA, Neut, FuncS	vhh-(+36GFP)

CAT	Product Name	Application	Type
MHH-101	Recombinant Human Anti-human BAX Antibody	ELISA, IF, FuncS	IgG

CAT	Product Name	Application	Type
MHH-101-F(E)	Recombinant Human Anti-human BAX Antibody Fab Fragment	ELISA, WB, FC, FuncS	Fab

CAT	Product Name	Application	Type
MHH-101-S(P)	Recombinant Human Anti-human BAX Antibody scFv Fragment	WB, Neut, FuncS	scFv

CAT	Product Name	Application	Type
PFBC-014	Mouse Anti-BAX Recombinant Antibody (clone 6A7); Fab Fragment	WB, FuncS	Mouse IgG

CAT	Product Name	Application	Type
PSBC-014	Mouse Anti-BAX Recombinant Antibody (clone 6A7); scFv Fragment	WB, FuncS	Mouse scFv

CAT	Product Name	Application	Type
TAB-0056CL-VHH	Llama Anti-BAX Recombinant Antibody (TAB-0056CL-VHH)	ELISA, FuncS, Apop, BI	Llama VHH

CAT	Product Name	Application	Type
TAB-0057CL-VHH	Llama Anti-BAX Recombinant Antibody (TAB-0057CL-VHH)	ELISA, FuncS, Apop, BI	Llama VHH

CAT	Product Name	Application	Type
TAB-0058CL-VHH	Llama Anti-BAX Recombinant Antibody (TAB-0058CL-VHH)	ELISA, FuncS, Apop, BI	Llama VHH

CAT	Product Name	Application	Type
TAB-0059CL-VHH	Llama Anti-BAX Recombinant Antibody (TAB-0059CL-VHH)	ELISA, FuncS, Apop, BI	Llama VHH

CAT	Product Name	Application	Type
MOB-0900MZ	Mouse Anti-BAX Recombinant Antibody (clone 6A7)	IHC-P	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-038CQ	Mouse Anti-BAX Recombinant Antibody (clone 2D2)	WB, IP, FC, IHC, Neut	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-0328	Hi-Affi™ Rabbit Anti-BAX Recombinant Antibody (clone DS328AB)	IHC-P	Rabbit IgG

CAT	Product Name	Application	Type
PABC-255	Rat Anti-BAX Recombinant Antibody (clone 3C10)	IP, ELISA, WB, Activ, Inhib	Rat IgG

CAT	Product Name	Application	Type
PFBC-255	Rat Anti-BAX Recombinant Antibody (clone 3C10); Fab Fragment	ELISA, WB, Inhib	Rat Fab

CAT	Product Name	Application	Type
PSBC-255	Rat Anti-BAX Recombinant Antibody (clone 3C10); scFv Fragment	ELISA, WB, Inhib	Rat scFv

CAT	Product Name	Application	Type
MRO-0155-CN	Rabbit Anti-BAX Recombinant Antibody (clone CBACN-060)	WB, IHC, IP, FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-2961LY-S(P)	Human Anti-BAX Recombinant Antibody; scFv Fragment (HPAB-2961LY-S(P))	ELISA, Inhib	Human scFv

CAT	Product Name	Application	Type
HPAB-2961LY-F(E)	Human Anti-BAX Recombinant Antibody; Fab Fragment (HPAB-2961LY-F(E))	ELISA, Inhib	Human Fab

CAT	Product Name	Application	Type
VS-0724-YC93	AbPlus™ Anti-Bax Magnetic Beads (VS-0724-YC93)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-1024-XY47	Mouse Anti-NHP BAX Recombinant Antibody (clone 2D2)	WB, IHC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0325-XY225	Anti-BAX Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS13-YC89	CytoStream™ Rabbit Anti-BAX Recombinant Antibody (VS13-YC89)	WB, IF, FC, IP	Rabbit IgG

CAT	Product Name	Application	Type
VS-0525-XY699	Anti-Mouse BAX Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY698	Anti-Human BAX Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-1025-YC174	Anti-BAX Antibody Prodrug, Protease Activated (3C10)	ISZ, Cyt, FuncS

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Humanized Anti-Dabigatran Recombinant Antibody (TAB-H40) (CAT# TAB-H40)
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC

Anti-ANGPT2 Recombinant Antibody (CAT# TAB-769)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Human Anti-TNFSF11 Recombinant Antibody (TAB-H18) (CAT# TAB-H18)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-Human CD22 Recombinant Antibody (TAB-176) (CAT# TAB-176)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (TAB-197) (CAT# TAB-197)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) (CAT# TAB-196)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human IL13 Recombinant Antibody (Anrukinzumab) (CAT# TAB-H05)
Application: ELISA, Inhib

Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) (CAT# TAB-188)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-C. difficile Toxin A Recombinant Antibody (TAB-716) (CAT# TAB-716)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Anti-Human IL5 Recombinant Antibody (TAB-031) (CAT# TAB-031)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) (CAT# TAB-H76)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human IL1 beta Recombinant Antibody (TAB-161) (CAT# TAB-161)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human GD2 Recombinant Antibody (hu14.18K322A) (CAT# TAB-304CL)
Application: FC, FuncS

Recombinant Human Anti-DENV E proteins Antibody (5J7) (CAT# PABL-067)
Application: ELISA, Neut, FuncS

Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5) (CAT# PABL-186)
Application: WB, Neut, FuncS

Human Anti-VEGF Recombinant Antibody (clone B20-4) (CAT# PABC-131)
Application: ELISA, Neut, Block

Mouse Anti-DOTA Recombinant Antibody (clone 2D12.5) (CAT# PABW-133)
Application: ELISA

Human Anti-C3b Recombinant Antibody (clone S77) (CAT# PABL-420)
Application: FuncS, Inhib, IP, ELISA

Human Anti-FGFR3 Recombinant Antibody (clone R3Mab) (CAT# PABL-474)
Application: ELISA

Mouse Anti-α4β7 Recombinant Antibody (PABL-746) (CAT# PABL-746)
Application: FC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.