Anti-CA6 (3ee9)-mc-vc-MMAE ADC (BAY-79-4620)
CAT#: ADC-L008
This ADC product is composed of an anti-CA6 antibody (clone 3ee9) conjuagated via a Mc-vc linker to MMAE (3ee9-mc-vc-MMAE). It has demonstrated a response in lymphoma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Normal Tissue
Figure 1 Salivary gland
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28550/63026_B_1_1.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (Daudi, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131686-CA6
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Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to CA6
- Clone
- 3ee9
- Antibody Conjugation
- Human
- Linker
- mc-vc (maleimidocaproyl-valine-alanine)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.
- Alternative Names
- CA-VI; GUSTIN
- Gene ID
- 765
- UniProt ID
- P23280
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Specific Binding To CA6
This product was instrumental in our lymphoma research. The fully human IgG1 clone 3ee9 showed specific binding to the carbonic anhydrase VI antigen. We observed the expected accumulation of cells in metaphase arrest due to the MMAE activity.
High Stability Peptide Linker
The mc-vc linker system demonstrated great systemic stability in our pre-incubation tests. Release of the drug was strictly dependent on lysosomal enzymes, which aligns well with our requirements for a stable antibody-drug conjugate for in vitro characterization.
Q&As
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What is the target antigen for the 3ee9 antibody clone?
A: The 3ee9 clone targets Carbonic Anhydrase VI (CA6). This protein is one of several isozymes of carbonic anhydrase and is typically found in salivary glands and saliva, where it may play a role in the reversible hydration of carbon dioxide.
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What class of linker is used in this conjugate?
A: This product uses an enzymatically cleavable peptide linker (mc-vc). This class of linkers is designed to be stable in the bloodstream but is cleaved by specific proteases, such as those found in the lysosome, upon internalization into the target cell.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CA6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-145 | Recombinant Anti-human CA6 Antibody | WB, FC, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-145-F(E) | Recombinant Anti-human CA6 Antibody Fab Fragment | ELISA, Nert, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-145-S(P) | Recombinant Anti-human CA6 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-145 | Recombinant Human Anti-human CA6 Antibody | ELISA, WB, IF, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-145-F(E) | Recombinant Human Anti-human CA6 Antibody Fab Fragment | ELISA, WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-145-S(P) | Recombinant Human Anti-human CA6 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC372 | SmartAb™ Recombinant Anti-CA6 pH-dependent Antibody (VS-0825-YC372) | WB, FC | Mouse IgG |
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