Anti-CA6 (3ee9)-mc-vc-MMAE ADC (BAY-79-4620) (CAT#: ADC-L008)

• Antibody Overview
• Fully human IgG1 monoclonal antibody that binds to CA6

• Clone
• 3ee9

• Antibody Conjugation
• Human

• Linker
• mc-vc (maleimidocaproyl-valine-alanine)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.

• Alternative Names
• CA-VI; GUSTIN

• Gene ID
• 765

• UniProt ID
• P23280

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