Anti-Human CA9 Recombinant Antibody (TAB-H43) (CAT#: TAB-H43)
Recombinant Chimeric antibody to Human CA9. It is based on an antibody and is being developed for the pre-surgical diagnosis of clear cell Renal Cell Cancer. It is the radioactively labelled form of the antibody Girentuximab. It binds specifically to a protein structure on the cell surface of malignant tumour cells. This protein structure, called Carbonic anhydrase IX (also CA-IX, MN or G250 antigen) is found on over 90 % of clear cell renal cell carcinomas, but not on normal renal tissue.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Immunofluorescent staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
Figure 2 Stomach
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
Specifications
- Host Species
- undefined
- Derivation
- Chimeric
- Type
- IgG1 - kappa
- Specificity
- CA9 (carbonic anhydrase IX, CAIX, MN, G250) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- ELISA, IP, IF, Inhib
- MW
- 146.5 kDa
- Related Disease
- Kidney tumours
Product Property
- Purity
- Purity >95% by SDS-PAGE.
Applications
- Application Notes
- The Human CA9 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Immunoprecipitation, Immunofluorescence, Inhibition.
Target
- Alternative Names
- iodine (124I) girentuximab;redectane;953400-68-5;CA9;carbonic anhydrase IX;carbonic anhydrase 9;CAIX;carbonic dehydratase;MN;RCC associated protein G250;pMW1;CA-IX;P54/58N;membrane antigen MN;carbonate dehydratase IX;RCC-associated antigen G250;RCC-associ
- Gene ID
- 768
- UniProt ID
- Q16790
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-707 | Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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