Anti-CASP7 Intrabody [(D-Arg)9] (IAB-B072(A))
Recombinant anti-CASP7 intrabody linked to (D-Arg)9 works within cells to bind human CASP7, expressed in CHO cells.
Specifications
- Immunogen
- human caspase 7, apoptosis-related cysteine peptidase
- Host
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Products can be used for: Western blot; Immunocytochemistry; Functional studies
Target
- Alternative Names
- Apoptosis related cysteine peptidase; Apoptosis related cysteine protease; Apoptotic protease MCH 3; Apoptotic protease Mch-3; Apoptotic protease MCH3; CASP 7; CASP-7; CASP7
- Entrez Gene ID
- 480
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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