Recombinant Anti-human CASP7 Intrabody [Tat]
CAT#: IAB-B072(T)
Recombinant anti-CASP7 intrabody in fusion with HIV Tat works within cells to bind human CASP7, expressed in CHO cells.
Gene Expression
Normal Tissue
Figure 1 Small intestine
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25563/59600_A_4_2.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25563/59600_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25563/59600_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25563/59600_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25563/59600_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165806-CASP7
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Specifications
- Immunogen
- human caspase 7, apoptosis-related cysteine peptidase
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Immunofluorescence; Flow Cytometry; Functional studies
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- Apoptosis related cysteine peptidase; Apoptosis related cysteine protease; Apoptotic protease MCH 3; Apoptotic protease Mch-3; Apoptotic protease MCH3; CASP 7; CASP-7; CASP7; CASP7_HUMAN; Caspase 7; Caspase 7 apoptosis related cysteine peptidase; Caspase
- Gene ID
- 480
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Related Signaling Pathways
TNF Signaling Pathway
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CASP7"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B072(A) | Recombinant Anti-human CASP7 Intrabody [(D-Arg)9] | WB, ICC, FuncS | scFv-(D-Arg)9 |
| IAB-B072(G) | Recombinant Anti-human CASP7 Intrabody [+36 GFP] | WB, ICC, Neut, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0478 | Hi-Affi™ Rabbit Anti-CASP7 Recombinant Antibody (clone DS478AB) | IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0867F | Mouse Anti-CASP7 Recombinant Antibody (clone MCH3 14 1-11) | WB | Mouse IgG |
| ZG-0868F | Mouse Anti-CASP7 Recombinant Antibody (clone MCH3-5) | WB | Mouse IgG |
| VS3-CJ1043 | Rabbit Anti-CASP7 Recombinant Antibody (VS3-CJ1043) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-XY166 | Mouse Anti-CASP7 Recombinant Antibody (clone 4D10B2) | IHC, FC | Mouse IgG1 |
| VS3-XY167 | Mouse Anti-CASP7 Recombinant Antibody (clone 2F11G1) | ELISA, WB, FC, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1356 | AbPlus™ Anti-CASP7 Magnetic Beads (VS-0724-YC1356) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY320 | Anti-CASP7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1007 | Anti-Mouse CASP7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1006 | Anti-Human CASP7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1008 | Anti-Rat CASP7 Immunohistochemistry Kit | IHC |
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