Human Anti-CCR5 Recombinant Antibody (clone huPR0140) (CAT#: HPAB-0047-YC)
The CC-chemokine receptor CCR5 is the major co-receptor for macrophage-tropic (R5) strains, and plays a crucial role in the sexual transmission of HIV-1 (4, 5, 21, 36). T cell line-tropic (X4) viruses use CXCR4 to enter target cells, and usually, but not always, emerge late in disease progression or as a consequence of virus propagation in tissue culture. Anti-CCR5 monoclonal antibodies have also shown the importance of the extracellular loops for viral entry
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Figure 1 pro 140 serum concentrations following a single intrawennous injection in HIV-infected invidulas
Provides PRO 140 serum concentrations following a single intravenous injection in HIV-infected individuals,and shows differences between 0.5 mg/kg (rep resented by a square),2 mg/kg (represented by a triangle, and 5 mg/kg (represented by a diamond) amounts.
Figure 2 emax analysis of antiviral data generated with IV and SC PRO 140, measure as Logo change in HIV-1 RNA versus AUC, mg * day/mL
Specifications
- Immunogen
- Immunized with L1.2-CCR5+ cells
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human CCR5
- Species Reactivity
- Human
- Clone
- huPR0140
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; C-C Motif Chemokine Receptor 5 A159A; Chemokine (C-C Motif) Receptor 5; Chemokine Receptor CCR5; CD195 Antigen; C-C CKR-5; CCCKR5; IDDM22; CD195; CKR-5; CKR5
- Gene ID
- 1234
- UniProt ID
- P51681
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-078 | Recombinant Anti-mouse Ccr5 VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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