Anti-CD18 Immunocytokine, ELAM-1-IgG (mAb 60.3) (ACFP-SH162)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD18 IgG to ELAM-1. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD18 as well as the biological activity of ELAM-1. This mAb is highly regarded among anti-CD18 antibodies in its ability to inhibit a plethora of leukocyte functions. This immunocytokine was designed for treating inhibit a plethora of leukocyte functions.
Specifications
- Target
- CD18
- Molecule Class
- ELAM-1-IgG2
- Species Reactivity
- Human
- Host
- Chimeric (Human-Mouse)
- Expression Host
- CHO
- Clone
- mAb 60.3
- Related Disease
- Leukocyte functions inhibition
- Cytokines 1
- ELAM-1
- Cytokines 1 Description
- E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part ininflammation. In humans, E-selectin is encoded by the SELE gene.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- ITGB2; integrin; beta 2; complement component 3 receptor 3 and 4 subunit; LAD; CD18; MF17; MFI7
- Entrez Gene ID
- 3689
- UniProt ID
- P05107
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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