Anti-CD18 Antibody-Cytokine Fusion Protein, ELAM-1-IgG (mAb 60.3)
CAT#: ACFP-SH162
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD18 IgG to ELAM-1. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD18 as well as the biological activity of ELAM-1. This mAb is highly regarded among anti-CD18 antibodies in its ability to inhibit a plethora of leukocyte functions. This immunocytokine was designed for treating inhibit a plethora of leukocyte functions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line BJ
Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
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Specifications
- Target
- CD18
- Molecule Class
- ELAM-1-IgG2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- mAb 60.3
- Related Disease
- Leukocyte functions inhibition
- Cytokine 1
- ELAM-1
- Cytokines 1 Description
- E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part ininflammation. In humans, E-selectin is encoded by the SELE gene.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
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Datasheet
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