Anti-CD18 Antibody-Cytokine Fusion Protein, ELAM-1-IgG (mAb 60.3) (CAT#: ACFP-SH162)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD18 IgG to ELAM-1. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD18 as well as the biological activity of ELAM-1. This mAb is highly regarded among anti-CD18 antibodies in its ability to inhibit a plethora of leukocyte functions. This immunocytokine was designed for treating inhibit a plethora of leukocyte functions.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Figure 2 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Figure 3 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Specifications
- Target
- CD18
- Molecule Class
- ELAM-1-IgG2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- mAb 60.3
- Related Disease
- Leukocyte functions inhibition
- Cytokine 1
- ELAM-1
- Cytokines 1 Description
- E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part ininflammation. In humans, E-selectin is encoded by the SELE gene.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- ITGB2; integrin; beta 2; complement component 3 receptor 3 and 4 subunit; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
- Gene ID
- 3689
- UniProt ID
- P05107
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-099 | Recombinant Anti-Human ITGB2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-044 | Anti-Human ITGB2 Recombinant Antibody (Rovelizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
| TAB-461CL | Human Anti-ITGB2 Recombinant Antibody (TAB-461CL) | ELISA | Human IgG |
| TAB-1582CL | Anti-Human ITGB2 Recombinant Antibody (Hu23F2G (also known as LeukArrest and Rovelizumab)) | IP, FuncS | Humanized antibody |
| TAB-1582CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
| TAB-1582CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1581CL | Anti-Human ITGB2 Recombinant Antibody (23F2G) | Inhib | |
| TAB-1581CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (23F2G) | Inhib | |
| TAB-1581CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (23F2G) | Inhib |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0298MZ | Chicken Anti-ITGB2 Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1590CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-48) | BL, FC, IHC-Fr, IHC-P, IP, WB | IgG1 |
| NEUT-1591CQ | Recombinant Mouse Anti-ITGB2 Antibody (TS1/18) | BL, FC, ICC/IF, IHC, WB | IgG1 |
| NEUT-1592CQ | Recombinant Mouse Anti-ITGB2 Antibody (YFC118.12) | FC, BL | IgG1, κ |
| NEUT-1593CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-148) | FC, IP, WB, BL, FuncS | IgG1 |
| NEUT-1594CQ | Recombinant Hamster Anti-Itgb2 Antibody (2E6) | BL, ICC, IP, FC | IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1884 | Hi-Affi™ Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (DS1884AB) | IP, WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203CQ | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3) | ELISA, WB, Block | Mouse IgG2a, κ |
| FAMAB-0204CQ | Human Anti-ITGB2 Recombinant Antibody (clone h60.3) | ELISA, WB, Block | Humanized IgG1, κ |
| FN-085CQ | Recombinant Rat Anti-ITGB2 Antibody (C71/16) | IHC-Fr, FC, IP, FuncS | Rat IgG2a |
| HPAB-1207WJ | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3) | ELISA | Human IgG |
| VS3-XY934 | Mouse Anti-ITGB2 Recombinant Antibody, FITC (clone 4ATS1/18.1.2.11) | FC, IF | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203CQ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); Fab Fragment | ELISA, WB, Block | Mouse Fab |
| FAMAB-0204CQ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone h60.3); Fab Fragment | ELISA, WB, Block | Human Fab |
| HPAB-1292WJ-F(E) | Rat Anti-ITGB2 Recombinant Antibody (clone YFC51.1); Fab Fragment | ELISA, FC | Rat Fab |
| HPAB-1293WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone LDP-01); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-1376WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone huH52) | ELISA, WB | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-044 | Afuco™ Anti-ITGB2 ADCC Recombinant Antibody (Rovelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1207WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); scFv Fragment | ELISA | Human scFv |
| HPAB-1292WJ-S(P) | Rat Anti-ITGB2 Recombinant Antibody (clone YFC51.1); scFv Fragment | ELISA, FC | Rat scFv |
| HPAB-1293WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone LDP-01); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-1376WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone huH52) | ELISA, WB | Human scFv |
| HPAB-1569WJ-S(P) | Mouse Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone 1B4) | ELISA, WB, IF | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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