Anti-CD18 Antibody-Cytokine Fusion Protein, GMP140-IgG (mAb 60.3)
CAT#: ACFP-SH163
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD18 IgG to GMP140. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD18 as well as the biological activity of GMP140. This mAb is highly regarded among anti-CD18 antibodies in its ability to inhibit a plethora of leukocyte functions. This immunocytokine was designed for treating inhibit a plethora of leukocyte functions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line BJ
Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
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Specifications
- Target
- CD18
- Molecule Class
- GMP140-IgG2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- mAb 60.3
- Related Disease
- Leukocyte functions inhibition
- Cytokine 1
- GMP140
- Cytokines 1 Description
- P-selectin is a protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules. Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM).
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
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