This antibody that binds to the human CD 19 antigen and that preferably mediates human ADCC can be used in the treatment of B cell diseases and disorders in human subjects, such as B cell malignancies.
Figure 1 B cell depletion by CD19 mAb in vivo.
Representative B cell depletion from blood, spleen, and lymph node 7 days after CD19 (HB12a, HB12b, or FMC63) or isotypematched
control (CTL) mAb treatment of mice as determined by immunofluorescence staining with flow cytometry analysis. Numbers indicate the percentage of gated lymphocytes.
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
Figure 2 B cell depletion by CD19 mAb in vivo.
Dose responses for spleen B cell depletion. hCD19TG mice were treated with CD19 or control (CTL) mAbs on day 0 with spleen B cells assessed on day 7 (n≥3).
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
Figure 3 B cell depletion by CD19 mAb in vivo.
Spleen B cell numbers (±SEM) 7 days after treatment of hCD19TG+/-mice with CD19 (filled bars, 50 μg) or control (open bars, 250 μg)mAb.
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-174 | Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Mouse IgG1, κ |
TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
TAB-1622CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) | ELISA, FC, Apop, ADCC, FuncS | Mouse IgG |
TAB-1623CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) | ELISA, FC | Mouse IgG |
TAB-1624CL | Anti-Human CD19 Recombinant Antibody (381) | FC, Inhib, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H17 | Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
TAB-1612CL | Human Anti-CD19 Recombinant Antibody (TAB-1612CL) | Depletion, FuncS | Humanized IgG1 |
TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G076E | Anti-CD19 immunotoxin HD37 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G076D | Anti-CD19 immunotoxin HD37 (IgG)-DT | Cytotoxicity assay, Function study | |
AGTO-G076R | Anti-CD19 immunotoxin HD37 (IgG)-RTA | Cytotoxicity assay, Function study | |
AGTO-G076S | Anti-CD19 immunotoxin HD37 (IgG)-Sap | Cytotoxicity assay, Function study | |
AGTO-G076P | Anti-CD19 immunotoxin HD37 (IgG)-PAP | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
TAB-1613CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) | Depletion, FuncS | Chimeric (mouse/human) Fab |
TAB-1614CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1614CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
TAB-1621CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1626CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12a) | Depletion | Fully human antibody |
TAB-1616CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1616CL-F(E)) | ELISA, WB | Human Fab |
TAB-1617CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1617CL-F(E)) | ELISA, WB | Human Fab |
TAB-1618CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1618CL-F(E)) | ELISA, WB | Human Fab |
TAB-1619CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1619CL-F(E)) | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0458LY | Human Anti-CD19 Recombinant Antibody (clone CBL001LY) | FC | Human IgG1 |
HPAB-0459LY | Human Anti-CD19 Recombinant Antibody (clone 1) | ELISA | Humanized IgG1 |
HPAB-0460LY | Human Anti-CD19 Recombinant Antibody (clone 2) | ELISA | Humanized IgG1 |
HPAB-0461LY | Human Anti-CD19 Recombinant Antibody (clone 3) | ELISA | Humanized IgG1 |
HPAB-0463LY | Mouse Anti-CD19 Recombinant Antibody (clone CBL002LY) | FC, in vitro cytotoxic, ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0023LY-F(E) | Humanized Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0023LY-F(E)) | WB | Fab |
HPAB-0036LY-F(E) | Humanized Anti-CD19 Antibody Fab Fragment (Hbu12) | WB | Fab |
HPAB-0418LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0418LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
HPAB-0419LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0419LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
HPAB-0420LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0420LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0986WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0986WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0987WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0987WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0989WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0989WJ-S(P)) | ELISA, FC | Human scFv |
FAMAB-0071WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone 25C1); scFv Fragment | WB, FC | Human scFv |
FAMAB-0072WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone BLY3); scFv Fragment | WB, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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