Human Anti-CD19 Recombinant Antibody (TAB-1627CL)
CAT#: TAB-1627CL
This antibody that binds to the human CD 19 antigen and that preferably mediates human ADCC can be used in the treatment of B cell diseases and disorders in human subjects, such as B cell malignancies.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Normal Tissue
Figure 3 Appendix
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
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Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Applications
- Depletion
- Related Disease
- B cell malignancies
Applications
- Application Notes
- This antibody has been tested for use in Depletion.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
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Minimal Cross-Reactivity
One of the standout features of HB12b is its specificity. We've found it to have minimal cross-reactivity, making it an exceptional tool for accurate identification of CD19. It outperforms many other antibodies on the market.
Superior to Other Antibodies
Having tested various CD19 antibodies, HB12b stands out with its superior specificity and sensitivity. It provides reliable results across different assays, making it our top choice.
Effective Blocking Protocol
HB12b requires an effective blocking protocol to achieve optimal results. We found using BSA or normal serum as blockers works well to reduce non-specific binding. Great antibody when used with proper blocking.
Q&As
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How can the Anti-Human CD19 Recombinant Antibody (HB12b) improve flow cytometry accuracy?
A: The HB12b antibody provides high specificity for CD19, ensuring accurate identification and sorting of B cells in flow cytometry by minimizing cross-reaction with other cellular markers.
-
Can the HB12b antibody be used for detecting CD19 in animal models?
A: Yes, though primarily designed for human CD19, cross-reactivity studies indicate potential applicability in some animal models. Validation should be performed case by case.
-
Is the Anti-Human CD19 Recombinant Antibody (HB12b) effective for depletion?
A: Yes, it has been proved to result B cell reduction in animal models for B lymphocyte malignancies and autoimmune disease.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (TAB-891) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1612CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) | Depletion, FuncS | Humanized scFv |
| TAB-1625CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (396) | Depletion, ELISA | Humanized antibody |
| TAB-1612CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) | Depletion, FuncS | Humanized Fab |
| TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L047E | anti-CD19 immunotoxin HD37 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L047D | anti-CD19 immunotoxin HD37 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L047R | anti-CD19 immunotoxin HD37 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L047S | anti-CD19 immunotoxin HD37 (scFv)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L047P | anti-CD19 immunotoxin HD37 (scFv)-PAP | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
| TAB-1620CL | Anti-Human CD19 Recombinant Antibody (HD37) | FuncS | |
| TAB-1622CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) | ELISA, FC, Apop, ADCC, FuncS | Mouse IgG |
| TAB-1623CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) | ELISA, FC | Mouse IgG |
| TAB-1624CL | Anti-Human CD19 Recombinant Antibody (381) | FC, Inhib, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1613CL | Human Anti-CD19 Recombinant Antibody (TAB-1613CL) | Cyt, FC, FuncS, Inhib | Chimeric (mouse/human) IgG1 |
| TAB-1614CL | Human Anti-CD19 Recombinant Antibody (TAB-1614CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1614CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) | FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1616CL | Human Anti-CD19 Recombinant Antibody (TAB-1616CL) | ELISA, WB | Human IgG |
| TAB-1617CL | Human Anti-CD19 Recombinant Antibody (TAB-1617CL) | ELISA, WB | Human IgG |
| TAB-1618CL | Human Anti-CD19 Recombinant Antibody (TAB-1618CL) | ELISA, WB | Human IgG |
| TAB-1619CL | Human Anti-CD19 Recombinant Antibody (TAB-1619CL) | ELISA, WB | Human IgG |
| TAB-1626CL | Human Anti-CD19 Recombinant Antibody (TAB-1626CL) | Depletion | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0458LY | Human Anti-CD19 Recombinant Antibody (clone CBL001LY) | FC | Human IgG1 |
| HPAB-0459LY | Human Anti-CD19 Recombinant Antibody (clone 1) | ELISA | Humanized IgG1 |
| HPAB-0460LY | Human Anti-CD19 Recombinant Antibody (clone 2) | ELISA | Humanized IgG1 |
| HPAB-0461LY | Human Anti-CD19 Recombinant Antibody (clone 3) | ELISA | Humanized IgG1 |
| HPAB-0463LY | Mouse Anti-CD19 Recombinant Antibody (clone CBL002LY) | FC, in vitro cytotoxic, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0117LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0117LY-S(P)) | ELISA | Humanized scfv |
| HPAB-0217-FY-S(P) | Human Anti-CD19 Recombinant Antibody scFv Fragment (HPAB-0217-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-0218-FY-S(P) | Human Anti-CD19 Recombinant Antibody scFv Fragment (HPAB-0218-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-0219-FY-S(P) | Human Anti-CD19 Recombinant Antibody scFv Fragment (HPAB-0219-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-0421-WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0421-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0117LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0117LY-F(E)) | ELISA | Humanized Fab |
| HPAB-3158LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3158LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3159LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3159LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3160LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3160LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3161LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3161LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-174) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC640 | AbPlus™ Anti-CD19 Magnetic Beads (VS-0724-YC640) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY83 | Mouse Anti-NHP CD19 Recombinant Antibody (clone PDR134) | WB, IF, FC | Mouse IgM, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY20 | CytoStream™ Mouse Anti-CD19 Recombinant Antibody (VS-0225-XY20) | FC | Mouse IgG1, kappa |
| VS13-YC154 | CytoStream™ Rabbit Anti-CD19 Recombinant Antibody (VS13-YC154) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY59 | Human Anti-CD19 (clone 2A3) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC75 | Recombinant Anti-CD19 Vesicular Antibody, EV Displayed (VS-0425-YC75) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1127 | Anti-Rat CD19 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1128 | Anti-Mouse CD19 Immunohistochemistry Kit | IHC |
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