Anti-Human CD19 Recombinant Antibody (HB12b) (CAT#: TAB-1627CL)
This antibody that binds to the human CD 19 antigen and that preferably mediates human ADCC can be used in the treatment of B cell diseases and disorders in human subjects, such as B cell malignancies.
Specific Inquiry
Depletion
Figure 1 B cell depletion by CD19 mAb in vivo.
Representative B cell depletion from blood, spleen, and lymph node 7 days after CD19 (HB12a, HB12b, or FMC63) or isotypematched
control (CTL) mAb treatment of mice as determined by immunofluorescence staining with flow cytometry analysis. Numbers indicate the percentage of gated lymphocytes.
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
Depletion
Figure 2 B cell depletion by CD19 mAb in vivo.
Dose responses for spleen B cell depletion. hCD19TG mice were treated with CD19 or control (CTL) mAbs on day 0 with spleen B cells assessed on day 7 (n≥3).
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
Depletion
Figure 3 B cell depletion by CD19 mAb in vivo.
Spleen B cell numbers (±SEM) 7 days after treatment of hCD19TG+/-mice with CD19 (filled bars, 50 μg) or control (open bars, 250 μg)mAb.
Yazawa, N., Hamaguchi, Y., Poe, J. C., & Tedder, T. F. (2005). Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences, 102(42), 15178-15183.
Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Clone
- HB12b
- Applications
- Depletion
- Related Disease
- B cell malignancies
Applications
- Application Notes
- This antibody has been tested for use in Depletion.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-174 | Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Mouse IgG1, κ |
| TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
| TAB-1611CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1611CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1622CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1622CL-S(P)) | ELISA, FC, Apop, ADCC, FuncS | Mouse scFv |
| TAB-1623CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1623CL-S(P)) | ELISA, FC | Mouse scFv |
Customer Reviews and Q&As
Customer Review
Q&As
-
Minimal Cross-Reactivity
One of the standout features of HB12b is its specificity. We've found it to have minimal cross-reactivity, making it an exceptional tool for accurate identification of CD19. It outperforms many other antibodies on the market. -
Superior to Other Antibodies
Having tested various CD19 antibodies, HB12b stands out with its superior specificity and sensitivity. It provides reliable results across different assays, making it our top choice. -
Effective Blocking Protocol
HB12b requires an effective blocking protocol to achieve optimal results. We found using BSA or normal serum as blockers works well to reduce non-specific binding. Great antibody when used with proper blocking.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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