Human Anti-CD19 Recombinant Antibody (TAB-1627CL) (CAT#: TAB-1627CL)
This antibody that binds to the human CD 19 antigen and that preferably mediates human ADCC can be used in the treatment of B cell diseases and disorders in human subjects, such as B cell malignancies.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Figure 2 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Figure 3 Appendix
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Applications
- Depletion
- Related Disease
- B cell malignancies
Applications
- Application Notes
- This antibody has been tested for use in Depletion.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L047E | anti-CD19 immunotoxin HD37 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L047D | anti-CD19 immunotoxin HD37 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L047R | anti-CD19 immunotoxin HD37 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L047S | anti-CD19 immunotoxin HD37 (scFv)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L047P | anti-CD19 immunotoxin HD37 (scFv)-PAP | Cytotoxicity assay, Functional assay |
Customer Reviews and Q&As
Customer Review
Q&As
Minimal Cross-Reactivity
One of the standout features of HB12b is its specificity. We've found it to have minimal cross-reactivity, making it an exceptional tool for accurate identification of CD19. It outperforms many other antibodies on the market.
Superior to Other Antibodies
Having tested various CD19 antibodies, HB12b stands out with its superior specificity and sensitivity. It provides reliable results across different assays, making it our top choice.
Effective Blocking Protocol
HB12b requires an effective blocking protocol to achieve optimal results. We found using BSA or normal serum as blockers works well to reduce non-specific binding. Great antibody when used with proper blocking.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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