Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B) (CAT#: ADC-L041)

• Antibody Overview
• Humanized IgG1 antibody hBU12ec (Anti-CD19)

• Clone
• hBU12ec

• Antibody Conjugation
• Humanized

• Linker
• mc-vc (maleimidocaproyl-valine-alanine)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• pyrrolobenzodiazepine (PBD) dimers SGD-1882

• Drug Class/Description
• Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

• Introduction
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

• Alternative Names
• B4; CVID3

• Gene ID
• 930

• UniProt ID
• P15391

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