Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B)
CAT#: ADC-L041
This ADC product is composed of an anti-CD19 antibody (clone hBU12ec) conjuagated via a mc-val linker to SGD-1882 (hBU12ec-mc-val-SGD-1882). It has demonstrated a response in NHL, AL treatment by a MOA (Mechanism of Action) of Bind to DNA minor groove and cause DNA damage.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Normal Tissue
Figure 3 Appendix
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
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Specifications
- Antibody Overview
- Humanized IgG1 antibody hBU12ec (Anti-CD19)
- Clone
- hBU12ec
- Antibody Conjugation
- Humanized
- Linker
- mc-vc (maleimidocaproyl-valine-alanine)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- pyrrolobenzodiazepine (PBD) dimers SGD-1882
- Drug Class/Description
- Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
Target
- Introduction
- Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
- Alternative Names
- B4; CVID3
- Gene ID
- 930
- UniProt ID
- P15391
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Related Diseases
Primary Immunodeficiency
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Datasheet
MSDS
COA
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