Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B)

Name: Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B)
SKU: ADC-L041
Rating: 5 (1 reviews)

CAT#: ADC-L041

This ADC product is composed of an anti-CD19 antibody (clone hBU12ec) conjuagated via a mc-val linker to SGD-1882 (hBU12ec-mc-val-SGD-1882). It has demonstrated a response in NHL, AL treatment by a MOA (Mechanism of Action) of Bind to DNA minor groove and cause DNA damage.

Gene Expression

Normal Tissue Figure 1 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg

Normal Tissue Figure 2 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg

Normal Tissue Figure 3 Appendix

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19

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Specifications

Antibody Overview
Humanized IgG1 antibody hBU12ec (Anti-CD19)

Clone
hBU12ec

Antibody Conjugation
Humanized

Linker
mc-vc (maleimidocaproyl-valine-alanine)

Linker Class/Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Drug
pyrrolobenzodiazepine (PBD) dimers SGD-1882

Drug Class/Description
Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

Target

Introduction
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Alternative Names
B4; CVID3

Gene ID
930

UniProt ID
P15391

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Related Diseases

Primary Immunodeficiency

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Datasheet

Datasheet - ADC-L041.pdf

MSDS

MSDS - ADC-L041.pdf

COA

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