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Anti-CD276 immunotoxin 8H9 (scFv)-PE (AGTO-G007E)

This immunotoxin was achieved by conjugating/fusing the Anti-CD276 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively bind to a cell surface glycoprotein expressed on human breast cancers; childhood sarcomas; and neuroblastomas. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating human breast cancers; childhood sarcomas and neuroblastomas.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
8H9
Molecule Class
scFv-PE
Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
human breast cancers, childhood sarcomas, and neuroblastomas
Target
Alternative Names
CD276; CD276 molecule; B7H3; B7-H3; B7RP-2; 4Ig-B7-H3; CD276 antigen; B7 homolog 3
Entrez Gene ID
80381
UniProt ID
Q5ZPR3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "CD276"
Recombinant Humanized Anti-CD276 Antibody scFv Fragment (hBRCA84D-2)    ( HPAB-0239-CN-S(P) )
Recombinant Rabbit Anti-CD276 Antibody scFv Fragment (S10-H50L58)    ( HPAB-0245-CN-S(P) )
Recombinant Humanized Anti-CD276 Antibody (hmAb-B)    ( HPAB-M0424-YC )
Recombinant Humanized Anti-CD276 Antibody Fab Fragment (hmAb-B)    ( HPAB-M0424-YC-F(E) )
Recombinant Human Anti-CD276 Antibody Fab Fragment (2-8)    ( HPAB-0243-CN-F(E) )
Recombinant Humanized Anti-CD276 Antibody (hmAb-C)    ( HPAB-M0426-YC )
Recombinant Mouse Anti-CD276 Antibody scFv Fragment (mAb-D)    ( HPAB-M0427-YC-S(P) )
Recombinant Rat Anti-CD276 Antibody (M3.2D7)    ( FN-232CQ )
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