Human Anti-CD28 Recombinant Antibody (TAB-065LC) (CAT#: TAB-065LC)
TAB-065LC is a type of humanized antibodies that target the human lymphocyte receptor CD28. When these antibodies are used in a monovalent form, they act as antagonists by blocking the CD28/B7 interaction without activating CD28. These antibodies can be used as therapeutic agents to block T cell activation through the CD28 receptor. In a dose-dependent manner, the monovalent antibody TAB-065LC reduces IL-2 synthesis by T cells.
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Normal Tissue
RNA Expression
Figure 1 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
Figure 2 Tonsil
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG, κ
- Specificity
- Human CD28
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Autoimmune diseases, Transplant rejection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Related Resources
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-365 | Mouse Anti-CD28 Recombinant Antibody (clone 1C6) | WB, ELISA, FuncS | Mouse IgG1 |
| MOB-0354MZ | Mouse Anti-CD28 Recombinant Antibody (clone DD29.1) | ELISA | Mouse IgG1 |
| HPAB-0132CQ | Human Anti-CD28 Recombinant Antibody (clone FR255734) | ELISA, IHC, Block, FuncS | Human IgG2M3, κ |
| HPAB-0245-FY | Mouse Anti-CD28 Recombinant Antibody (HPAB-0245-FY) | WB, IP, IF, FC | Mouse IgG1 |
| FN-227CQ | Mouse Anti-CD28 Recombinant Antibody (clone JJ319) | FC, FuncS | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
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