Mouse Anti-CD28 Recombinant Antibody (clone 1C6) (CAT#: PABL-365)

Figure 1 Histopathology of 4 dogs treated with anti-CD28 (1C6) mAb.

The top left panel shows H520 necropsy lung section at 100× magnification demonstrating edema (top arrow), dense lymphocytic infiltrate (middle arrow), and hemorrhage (bottom arrow). The middle left panel shows H520 necropsy lung section at 250× magnification after antimouse peroxidase polymer staining of deparaffinized lung section (arrow points to pulmonary macrophages coated with anti-CD28 mAb). The bottom left panel shows 250× magnification of antirabbit peroxidase polymer control. The top middle panel shows H517 necropsy small intestine section at 100× magnification demonstrating significant hemorrhage on the tips of the villi. The center middle row shows normal small bowel at100× magnification for comparison. The bottom center panel shows H208 necropsy small intestine section at 100× magnification; the arrow points to an enlarged and densely packed Peyer patch. The top right and middle right panel shows H514 necropsy lymph node section at 100× (top) and 250× (middle) magnifications; the arrows point to apoptotic bodies. Slides are stained by hematoxylin and eosin unless otherwise noted.

Rosinski, S. L., Storb, R., Strong, R. K., Sale, G. E., Stone, D. M., Gewe, M. M., ... & Graves, S. S. (2015). Anti-CD28 antibody-initiated cytokine storm in canines. Transplantation direct, 1(2).