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Anti-CD37 (AGS67C)-mc-val-cit-PABC-MMAE ADC (AGS67E) (CAT#: ADC-L005)

This ADC product is composed of an anti-CD37 antibody (clone AGS67C) conjuagated via a mc-val-cit-PABC linker to MMAE (AGS67C-mc-val-cit-PABC-MMAE). It has demonstrated a response in pancreatic cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HEL
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Figure 5 Spleen
Figure 5 Spleen
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37

Specifications

  • Antibody Overview
  • Fully human IgG2k monoclonal antibody that binds to CD-37
  • Clone
  • AGS67C
  • Antibody Conjugation
  • Human
  • Linker
  • mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • GP52-40; TSPAN26

Downloads

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See other products for "CD37"

Humanized Antibody

CAT Product Name Application Type
TAB-904 Anti-Human CD37 Recombinant Antibody (Otlertuzumab) ELISA, IP, FC, FuncS, Neut, IF, ICC VH - V-kappa - CH2 - CH3

Chimeric Antibody

CAT Product Name Application Type
TAB-0272CL Anti-Human CD37 Recombinant Antibody (chHH1.1,) ELISA, WB Chimeric (mouse/human)
TAB-0273CL Anti-Human CD37 Recombinant Antibody (chHH1.3) Block Chimeric (mouse/human)
TAB-0272CL-S(P) Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.1,) ELISA, WB Chimeric (mouse/human)
TAB-0273CL-S(P) Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.3) Block Chimeric (mouse/human)
TAB-0272CL-F(E) Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.1,) ELISA, WB Chimeric (mouse/human)

Recombinant Antibody

CAT Product Name Application Type
MOB-0492CT Mouse Anti-CD37 Recombinant Antibody (clone 3C9) ELISA, IF, WB Mouse IgG1
HPAB-0159-FY Mouse Anti-CD37 Recombinant Antibody (HPAB-0159-FY) Activ, Depletion, FuncS, Inhib Mouse IgG2a
HPAB-0163-FY Mouse Anti-CD37 Recombinant Antibody (HPAB-0163-FY) FC, Inhib, FuncS Mouse IgG
HPAB-0164-FY Mouse Anti-CD37 Recombinant Antibody (HPAB-0164-FY) FC, Inhib, CDC, FuncS Mouse IgG
HPAB-1045-FY Human Anti-CD37 Recombinant Antibody (HPAB-1045-FY) FC, ELISA Humanized IgG

Mouse Antibody

CAT Product Name Application Type
TAB-467CQ Anti-Human CD37 Recombinant Antibody (Lilotomab) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-467CQ Afuco™ Anti-CD37 ADCC Recombinant Antibody (Lilotomab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-AP033-YC-S(P) Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment FuncS Human scFv
HPAB-AP034-YC-S(P) Human Anti-CD37 Recombinant Antibody (clone B2); scFv Fragment FuncS Human scFv
HPAB-0004-SJF-S(P) Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0004-SJF-S(P)) ELISA, IHC, FuncS Mouse scFv
HPAB-0006-SJF-S(P) Mouse Anti-CD37 Recombinant Antibody (clone A0); scFv Fragment FACS, FuncS Mouse scFv
HPAB-0009-SJF-S(P) Human Anti-CD37 Recombinant Antibody (clone CAS-024); scFv Fragment FuncS Humanized scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-AP033-YC-F(E) Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment FuncS Human Fab
HPAB-AP034-YC-F(E) Human Anti-CD37 Recombinant Antibody (clone B2); Fab Fragment FuncS Human Fab
HPAB-0004-SJF-F(E) Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0004-SJF-F(E)) ELISA, IHC, FuncS Mouse Fab
HPAB-0006-SJF-F(E) Mouse Anti-CD37 Recombinant Antibody (clone A0); Fab Fragment FACS, FuncS Mouse Fab
HPAB-0009-SJF-F(E) Human Anti-CD37 Recombinant Antibody (clone CAS-024); Fab Fragment FuncS Humanized Fab

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