Anti-CD37 (AGS67C)-mc-val-cit-PABC-MMAE ADC (AGS67E)
CAT#: ADC-L005
This ADC product is composed of an anti-CD37 antibody (clone AGS67C) conjuagated via a mc-val-cit-PABC linker to MMAE (AGS67C-mc-val-cit-PABC-MMAE). It has demonstrated a response in pancreatic cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
❮
❯
Specifications
- Antibody Overview
- Fully human IgG2k monoclonal antibody that binds to CD-37
- Clone
- AGS67C
- Antibody Conjugation
- Human
- Linker
- mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
- Alternative Names
- GP52-40; TSPAN26
- Gene ID
- 951
- UniProt ID
- P11049
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-L005. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD37"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Human Anti-CD37 Recombinant Antibody (TAB-0272CL) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0273CL-S(P)) | Block | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) | Activ, Depletion, FuncS, Inhib | Mouse scFv |
| HPAB-0163-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0163-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-0004-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0004-SJF-S(P)) | ELISA, IHC, FuncS | Mouse scFv |
| HPAB-0006-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody (clone A0); scFv Fragment | FACS, FuncS | Mouse scFv |
| HPAB-0009-SJF-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (HPAB-0009-SJF-S(P)) | FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
| HPAB-0901-WJ-F(E) | Mouse Anti-CD37 Recombinant Antibody Fab Fragment (HPAB-0901-WJ-F(E)) | FC | Mouse Fab |
| HPAB-0004-SJF-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0004-SJF-F(E)) | ELISA, IHC, FuncS | Mouse Fab |
| HPAB-0006-SJF-F(E) | Mouse Anti-CD37 Recombinant Antibody (clone A0); Fab Fragment | FACS, FuncS | Mouse Fab |
| HPAB-0009-SJF-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (HPAB-0009-SJF-F(E)) | FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0901-WJ | Mouse Anti-CD37 Recombinant Antibody (HPAB-0901-WJ) | FC | Human IgG |
| HPAB-0004-SJF | Mouse Anti-CD37 Recombinant Antibody (HPAB-0004-SJF) | ELISA, IHC, FuncS | Mouse IgG |
| HPAB-0006-SJF | Mouse Anti-CD37 Recombinant Antibody (clone A0) | FACS, FuncS | Mouse IgG |
| HPAB-0009-SJF | Human Anti-CD37 Recombinant Antibody (HPAB-0009-SJF) | FuncS | Humanized IgG1 |
| VS11-QX31 | Mouse Anti-CD37 Recombinant Antibody [clone IPO-24 (ZC37-24)] | FC, IF, IHC | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC9 | Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: FC, IHC, FuncS, Inhib, Cyt
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: ELISA, Vaccine, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
