CD40 is a cell surface phosphorylated glycoprotem that is expressed on a variety of cell types, including B cells, B cell malignancies, follicular dendritic cells, basal epithelial cells, and carcinomas. CD40 binds CD40 ligand ("CD40L").
Figure 1 Activation potential of a panel of anti-CD40 antibodies measured as [methyl-³H]thymidine uptake of tonsilla B cells after addition of anti-CD40 monoclonal antibodies (MoAbs).
The experiments were performed using 1 µg/ml in three independent experiments.
Hager, A. C. M., Ellmark, P., Borrebaeck, C. A. K., & Furebring, C. (2003). Affinity and Epitope Profiling of Mouse Anti‐CD40 Monoclonal Antibodies. Scandinavian journal of immunology, 57(6), 517-524.
Figure 2 Ability of anti-CD40 mAb to co-stimulate anti-IgM-induced human B-cell proliferation.
Human tonsillar B cells (4 x 10⁴/well) were cultured in 200 ul in microwells in the presence of anti-IgM coupled to Sepharose beads (5 yg/ml) (a) or in the presence of anti-IgM plus rIL-2 (100 U/ml) (b). Varying concentrations of the anti-CD40 mAb S2C6,5D12, 3C6 or 3A8 were added and [³H]thymidine incorporation was estimated at day 3 after 18 hr pulsing. Data presented in (a) are means derived from experiments with B-cell preparations from three different donors with duplicate incubations. Data in (b) are means of duplicate incubations from one experiment out of two with comparable results.
Kwekkeboom, J., De Boer, M., Tager, J. M., & De Groot, C. (1993). CD40 plays an essential role in the activation of human B cells by murine EL4B5 cells. Immunology, 79(3), 439.
Figure 3 Effect of anti-CD40 mAb G28.5 and S2C6 on EL4B5-induced human B-cell proliferation.
Human tonsillar B cells were cultured together with irradiated EL4B5 cells. Varying concentrations of anti-CD40 mAb G28.5 and S2C6 were added. As an isotype-matched control mAb MOPC-21 (IgGl) was used. Data are means + SD derived from three experiments with duplicate incubations. Actual [³H]thymidine incorporations found in the absence of antibody were 6982 + 1729, 4362 + 1020 and 14,809 2791 c.p.m. respectively
Kwekkeboom, J., De Boer, M., Tager, J. M., & De Groot, C. (1993). CD40 plays an essential role in the activation of human B cells by murine EL4B5 cells. Immunology, 79(3), 439.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G079E | Anti-CD40 immunotoxin G28-5 (scFv)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-126CL | Human Anti-CD40 Recombinant Antibody (TAB-126CL) | Block, Cyt, FuncS, Inhib | Human IgG |
TAB-189LC | Anti-Human CD40 Recombinant Antibody (F4) | SPR, ELISA | Humanized antibody |
TAB-190LC | Anti-Human CD40 Recombinant Antibody (L3.17) | SPR, ELISA | Humanized antibody |
TAB-194LC | Human Anti-CD40 Recombinant Antibody (TAB-194LC) | ELISA | Humanized IgG1, κ |
TAB-200LC | Human Anti-CD40 Recombinant Antibody (TAB-200LC) | ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-188LC | Anti-Human CD40 Recombinant Antibody (chi220) | SPR, ELISA, Inhib, FuncS | Chimeric antibody (mouse/human) |
TAB-202LC | Anti-CD40 Recombinant Antibody (TAB-202LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG1 |
TAB-203LC | Anti-CD40 Recombinant Antibody (TAB-203LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG4 |
TAB-188LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
TAB-202LC-F(E) | Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-202LC-F(E)) | FC, ELISA | Chimeric antibody (mouse/rhesus) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-207LC | Mouse Anti-CD40 Recombinant Antibody (TAB-207LC) | ELISA | Mouse IgG, κ |
TAB-208LC | Mouse Anti-CD40 Recombinant Antibody (TAB-208LC) | ELISA | Mouse IgG, κ |
TAB-209LC | Mouse Anti-CD40 Recombinant Antibody (TAB-209LC) | ELISA | Mouse IgG, κ |
TAB-207LC-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-207LC-F(E)) | ELISA | Mouse Fab |
TAB-208LC-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-208LC-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-195LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P)) | ELISA | Human scFv |
TAB-196LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P)) | ELISA | Human scFv |
TAB-197LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P)) | ELISA | Human scFv |
TAB-198LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P)) | ELISA | Human scFv |
TAB-470CQ | Anti-Human CD40 Recombinant Antibody (Selicrelumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1129MZ | Mouse Anti-CD40 Recombinant Antibody (clone 93206) | ELISA | Mouse IgG2b |
HPAB-0162-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0162-YC) | FC | Human IgG |
HPAB-0163-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0163-YC) | FC | Human IgG |
HPAB-1662LY | Mouse Anti-CD40 Recombinant Antibody (HPAB-1662LY) | ELISA, RIA, Antagonist | Mouse IgG |
HPAB-1663LY | Mouse Anti-CD40 Recombinant Antibody (HPAB-1663LY) | ELISA, RIA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-362CQ | Human Anti-CD40 Recombinant Antibody (clone 5D12) | Block, ELISA, FC, SPR, IP, IHC | Human IgG4, κ |
NEUT-363CQ | Mouse Anti-CD40 Recombinant Antibody (clone 5C3) | FC, Block, Activ | Mouse IgG1, κ |
NEUT-365CQ | Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) | FC, Block, Costim, IHC | Hamster IgM |
NEUT-366CQ | Rat Anti-CD40 Recombinant Antibody (clone MAB0819) | Block, Activ | Rat IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-364CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL829) | WB, Neut | Mouse IgG2b, κ |
NEUT-367CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL013) | WB, IHC, Neut | Mouse IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4059 | Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-105LC | Human Anti-CD40 Recombinant Antibody (MOB-105LC) | FC, FuncS | Human IgG1, κ |
MOB-106LC | Human Anti-CD40 Recombinant Antibody (MOB-106LC) | FC, FuncS, ELISA | Human IgG2, κ |
MOB-107LC | Human Anti-CD40 Recombinant Antibody (MOB-107LC) | FC, FuncS, ELISA | Human IgG2, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-021CN | Human Anti-CD40 Recombinant Antibody (NS-021CN) | ELISA, IF, Block, FuncS | Human IgG |
NS-021CN-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E)) | ELISA | Human Fab |
NS-021CN-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1662LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1663LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1664LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1665LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1665LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1666LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1666LY-F(E)) | ELISA, RIA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-152 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-262 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Teneliximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
AFC-TAB-759 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Lucatumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-470CQ | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-006ML | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Bleselumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1672-FY-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1672-FY-F(E)) | Inhib | Human Fab |
HPAB-1119WJ-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1119WJ-S(P)) | ELISA, WB | Mouse scFv |
HPAB-1120WJ-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1120WJ-S(P)) | ELISA, WB | Mouse scFv |
HPAB-1833-FY-F(E) | Human Anti-CD40 Recombinant Antibody (clone 3.1.1); scFv Fragment | Activ | Human scFv |
HPAB-1834-FY-F(E) | Human Anti-CD40 Recombinant Antibody (clone 21.4.1); scFv Fragment | Agonist, Activ | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1218WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-1) | ELISA | Llama VHH |
HPAB-1219WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-2) | ELISA | Llama VHH |
HPAB-1220WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-3) | ELISA | Llama VHH |
There are currently no Customer reviews or questions for HPAB-0166-YC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.