Is this antibody suitable for immunoprecipitation?

Yes, Lucatumumab (clone TAB-759) is suitable for use in Immunoprecipitation (IP), as well as ELISA, Flow Cytometry (FC), Functional Studies (FuncS), Immunofluorescence (IF), Neutralization (Neut), and Immunohistochemistry (IHC).

What is the isotype of Lucatumumab?

Lucatumumab is a Human monoclonal antibody with an IgG1 - kappa isotype. It is expressed in CHO cells and binds to human CD40. It is investigated for research into various types of cancer like multiple myeloma and lymphoma.

Anti-CD40 Recombinant Antibody (Lucatumumab)

CAT#: TAB-759

Recombinant human monoclonal antibody expressed in CHO binding to human CD40. Lucatumumab is a human monoclonal antibody being investigated for the treatment of various types of cancer like multiple myeloma, non-Hodgkin's or Hodgkin's lymphoma.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG1 - kappa

Species Reactivity
Human

Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.

CAS
903512-50-5

Generic Name
lucatumumab

UNII
P0EP9VFC4R

MW
146 kDa

Related Disease
Chronic lymphocytic leukemia (CLL)

Product Property

Purity
Purity >95% by SDS-PAGE.

Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

Alternative Names
CD40 Molecule; CD40 Molecule, TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily, Member 5

Gene ID
958

UniProt ID
P25942

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Breast cancer biomarkers at key points during disease progression

Versatile For Multiple APPs

Lucatumumab (TAB-759) has been an incredibly versatile reagent in our lab. We have successfully used it in Flow Cytometry, ELISA, and Immunoprecipitation to study CD40. Its high purity (>95%) and specific binding to human CD40 make it a reference standard for our B-cell lymphoma research.

Strong Functional Activity

We tested this recombinant human monoclonal antibody in functional studies (FuncS) and neutralization assays. It showed strong activity and bound effectively to the target on the cell surface. It is an essential tool for our work on understanding the role of CD40 in non-Hodgkin's lymphoma models.

Q&As

Is this antibody suitable for immunoprecipitation?

A: Yes, Lucatumumab (clone TAB-759) is suitable for use in Immunoprecipitation (IP), as well as ELISA, Flow Cytometry (FC), Functional Studies (FuncS), Immunofluorescence (IF), Neutralization (Neut), and Immunohistochemistry (IHC).
What is the isotype of Lucatumumab?

A: Lucatumumab is a Human monoclonal antibody with an IgG1 - kappa isotype. It is expressed in CHO cells and binds to human CD40. It is investigated for research into various types of cancer like multiple myeloma and lymphoma.

View the frequently asked questions answered by Creative Biolabs Support.

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Biosimilar Overview

Please refer to Lucatumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lucatumumab.

Related Diseases

Asthma

Systemic Lupus Erythematosus

Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-759.pdf

MSDS

MSDS - TAB-759.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-759)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human CD40. It is a human monoclonal antibody being investigated for the treatment of various types of cancer like multiple myeloma, non-Hodgkin's or Hodgkin's lymphoma.

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