Anti-CD40 immunotoxin (scFv)-PE
CAT#: AGTO-G079E
This immunotoxin was achieved by conjugating/fusing the Anti-CD40 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Non-Hodgkin's lymphoma and multiple myeloma.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Non-Hodgkin's lymphoma and multiple myeloma
Target
- Alternative Names
- CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE103
- Gene ID
- 958
- UniProt ID
- P25942
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Related Diseases
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1110LY | Mouse Anti-CD40 Recombinant Antibody (clone CBL020) | ELISA | Mouse IgG |
| HPAB-0118-YJ | Human Anti-CD40 Recombinant Antibody (HPAB-0118-YJ) | FuncS | Human IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262 | Anti-Human CD40 Recombinant Antibody (TAB-262) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 |
| TAB-188LC | Anti-Human CD40 Recombinant Antibody (chi220) | SPR, ELISA, Inhib, FuncS | Chimeric antibody (mouse/human) |
| TAB-202LC | Anti-CD40 Recombinant Antibody (TAB-202LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG1 |
| TAB-203LC | Anti-CD40 Recombinant Antibody (TAB-203LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG4 |
| TAB-188LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-152 | Anti-Human CD40 Recombinant Antibody (TAB-152) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-189LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (F4) | SPR, ELISA | Humanized antibody |
| TAB-190LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (L3.17) | SPR, ELISA | Humanized antibody |
| TAB-194LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-194LC-S(P)) | ELISA | Humanized scFv |
| TAB-200LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-200LC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0061CL | Anti-Human CD40 Recombinant Antibody (PPAT-071-01) | ELISA, ADCC, CDC, FuncS | |
| TAB-0062CL | Anti-Human CD40 Recombinant Antibody (PPAT-071-02) | ELISA, ADCC, CDC, FuncS | |
| TAB-0063CL | Anti-Human CD40 Recombinant Antibody (PPAT-071-03) | ELISA, ADCC, CDC, FuncS | |
| TAB-0064CL | Anti-Human CD40 Recombinant Antibody (PPAT-071-04) | ELISA, ADCC, CDC, FuncS | |
| TAB-0065CL | Anti-Human CD40 Recombinant Antibody (PPAT-071-05) | ELISA, ADCC, CDC, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P)) | ELISA | Human scFv |
| TAB-196LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P)) | ELISA | Human scFv |
| TAB-197LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P)) | ELISA | Human scFv |
| TAB-198LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P)) | ELISA | Human scFv |
| TAB-470CQ | Anti-Human CD40 Recombinant Antibody (Selicrelumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-362CQ | Human Anti-CD40 Recombinant Antibody (clone 5D12) | Block, ELISA, FC, SPR, IP, IHC | Human IgG4, κ |
| NEUT-363CQ | Mouse Anti-CD40 Recombinant Antibody (clone 5C3) | FC, Block, Activ | Mouse IgG1, κ |
| NEUT-366CQ | Rat Anti-CD40 Recombinant Antibody (clone MAB0819) | Block, Activ | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-364CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL829) | WB, Neut | Mouse IgG2b, κ |
| NEUT-367CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL013) | WB, IHC, Neut | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-365CQ | Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) | FC, Block, Costim, IHC | Hamster IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4059 | Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-105LC | Human Anti-CD40 Recombinant Antibody (MOB-105LC) | FC, FuncS | Human IgG1, κ |
| MOB-106LC | Human Anti-CD40 Recombinant Antibody (MOB-106LC) | FC, FuncS, ELISA | Human IgG2, κ |
| MOB-107LC | Human Anti-CD40 Recombinant Antibody (MOB-107LC) | FC, FuncS, ELISA | Human IgG2, κ |
| VS-0724-XY18 | Mouse Anti-CD40 Agonistic Antibody (VS-0724-XY18) | FC, Agonistic assays, CyTOF®, ICC | Mouse IgG2b |
| VS-0724-XY19 | Rat Anti-Cd40 Agonistic Antibody (VS-0724-XY19) | FC, IP, Agonistic assays, CyTOF® | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-021CN | Human Anti-CD40 Recombinant Antibody (NS-021CN) | ELISA, IF, Block, FuncS | Human IgG |
| NS-021CN-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E)) | ELISA | Human Fab |
| NS-021CN-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110LY-S(P) | Mouse Anti-CD40 Recombinant Antibody (clone CBL020); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1662LY-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1662LY-S(P)) | ELISA, RIA | Mouse scfv |
| HPAB-1663LY-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1663LY-S(P)) | ELISA, RIA | Mouse scfv |
| HPAB-1664LY-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1664LY-S(P)) | ELISA, RIA | Mouse scfv |
| HPAB-1665LY-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1665LY-S(P)) | ELISA, RIA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1662LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1663LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1664LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1665LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1665LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1666LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1666LY-F(E)) | ELISA, RIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-152 | Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-152) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-262 | Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-262) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-759 | Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-759) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-470CQ | Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-470CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-006ML | Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1218WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1218WJ) | ELISA | Llama VHH |
| HPAB-1219WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1219WJ) | ELISA | Llama VHH |
| HPAB-1220WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1220WJ) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1328 | AbPlus™ Anti-CD40 Magnetic Beads (VS-0724-YC1328) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC117 | Mouse Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC117), CDC Enhanced | ELISA, ADCC, CDC | Antibody hexamer |
| VS-0924-YC118 | Human Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC118), CDC Enhanced | ELISA, Block, FC, IF, Activ, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY52 | CytoStream™ Armenian Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) | FC, Block | Armenian Hamster IgM, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY89 | Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera | FC, WB, Agonist | Rat IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC514 | Recombinant Anti-CD40 Vesicular Antibody, EV Displayed (VS-0425-YC514) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1181 | Anti-CD40 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC30 | Recombinant Anti-CD40 (CRD1 x ECD) Biparatopic Antibody, Tandem scFv | ELISA, FC, Neut, IHC, IP, IF | Tandem scFv |
| VS-0525-YC206 | Recombinant Anti-CD40 (CRD2 x CRD1) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IHC, IP | Tandem scFv |
| VS-0525-YC208 | Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab) | ELISA, FC, IP, IF, IHC | Tandem scFv |
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