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    Anti-CD40 immunotoxin (scFv)-PE (CAT#: AGTO-G079E)

    This immunotoxin was achieved by conjugating/fusing the Anti-CD40 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Non-Hodgkin's lymphoma and multiple myeloma.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Lymph node
    Figure 1 Lymph node
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
    Figure 2 Tonsil
    Figure 2 Tonsil
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
    RNA Expression
    Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
    Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
    Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
    Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Molecule Class
    • scFv-PE
    • Toxin Description
    • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • Non-Hodgkin's lymphoma and multiple myeloma

    Target

    • Alternative Names
    • CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE103

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    CAT Product Name Application Type
    TAB-262 Anti-Human CD40 Recombinant Antibody (TAB-262) IP, IF, FuncS, FC, Neut, ELISA, ICC IgG1
    TAB-188LC Anti-Human CD40 Recombinant Antibody (chi220) SPR, ELISA, Inhib, FuncS Chimeric antibody (mouse/human)
    TAB-202LC Anti-CD40 Recombinant Antibody (TAB-202LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG1
    TAB-203LC Anti-CD40 Recombinant Antibody (TAB-203LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG4
    TAB-188LC-S(P) Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) SPR, ELISA Chimeric antibody (mouse/human)

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