Anti-Human CD6 Recombinant Antibody (TAB-247) (CAT#: TAB-247)
Recombinant monoclonal antibody to CD6. It is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. It, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation.
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Normal Tissue
RNA Expression
Figure 1 High expression in lymph node.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
Figure 2 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
Figure 5 Tonsil
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ
- Related Disease
- Psoriasis
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The CD6 antibody has been reported in applications of WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ.
Target
- Alternative Names
- Itolizumab;Alzumab;1116433-11-4;T1h;Alzumab;CD6;CD6 molecule;CD6 antigen;T-cell differentiation antigen CD6;Tp120;T12;TP120;FLJ44171;
- Gene ID
- 923
- UniProt ID
- P30203
Related Resources
Please refer to Itolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Itolizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1416z | Mouse Anti-CD6 Recombinant Antibody (clone 23C11) | WB, FC, IHC, FuncS | Mouse IgG1, κ |
| MOB-1778MZ | Recombinant Mouse Anti-Human CD6 Antibody (clone NBF-2D20), APC-Conjugated | FC | Mouse antibody |
| FN-023CQ | Mouse Anti-CD6 Recombinant Antibody (clone CBL-1300) | FC, FuncS, WB | Mouse IgG1, κ |
| FAMAB-1643CQ | Mouse Anti-CD6 Recombinant Antibody (clone OX52) | IP, FC, IHC-Fr | Mouse IgG2a |
| FAMAB-1644CQ | Mouse Anti-CD6 Recombinant Antibody (clone OX129) | FC, IF | Mouse IgG2a |
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(Creative Biolabs Cat# TAB-247, RRID: AB_3111898)
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