Anti-Human CD6 Recombinant Antibody (TAB-247)
CAT#: TAB-247
Recombinant monoclonal antibody to CD6. It is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. It, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ
- Related Disease
- Psoriasis
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The CD6 antibody has been reported in applications of WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ.
Target
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(Creative Biolabs Cat# TAB-247, RRID: AB_3111898)
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Biosimilar Overview
Please refer to Itolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Itolizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CD6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-325LC | Human Anti-CD6 Recombinant Antibody (TAB-325LC) | Cyt, FC | Humanized antibody |
| TAB-325LC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (TAB-325LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-325LC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (TAB-325LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1778MZ | Recombinant Mouse Anti-Human CD6 Antibody (clone NBF-2D20), APC-Conjugated | FC | Mouse antibody |
| HPAB-N0043-YC | Human Anti-CD6 Recombinant Antibody (HPAB-N0043-YC) | ELISA, FC | Humanized IgG |
| VS3-XY385 | Mouse Anti-CD6 Recombinant Antibody (clone 1G6A4) | ELISA, WB, IHC, FC | Mouse IgG2b |
| VS3-XY386 | Mouse Anti-CD6 Recombinant Antibody (clone 2D12C6) | ELISA, WB, IHC, FC | Mouse IgG2b |
| VS3-XY387 | Mouse Anti-CD6 Recombinant Antibody (clone 8D5B4C11) | ELISA, WB, IHC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-399CQ | Mouse Anti-CD6 Recombinant Antibody (clone OX-124) | Block | Mouse IgG1, κ |
| NEUT-400CQ | Human Anti-CD6 Recombinant Antibody (clone OX-126) | FC, IHC, IF, FuncS, Depletion, Block | Human IgG1, κ |
| NEUT-401CQ | Rat Anti-Cd6 Recombinant Antibody (clone CBL311) | Block | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0573 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS573AB) | IHC-P, IP, WB | Rabbit IgG |
| MOR-0574 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS574AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-247 | Afuco™ Anti-CD6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-247) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (HPAB-N0043-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0009-YJ-S(P) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); scFv Fragment | FuncS, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (HPAB-N0043-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0009-YJ-F(E) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); Fab Fragment | FuncS, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY63 | CytoStream™ Rat Anti-CD6 Recombinant Antibody (VS-0225-XY63) | FC | Rat IgG2a, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY90 | Mouse Anti-CD6 (clone IOR-T1) scFv-Fc Chimera | ELISA | Mouse IgG2a, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC197 | Recombinant Anti-CD6 Vesicular Antibody, EV Displayed (VS-0425-YC197) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1206 | Anti-CD6 Immunohistochemistry Kit | IHC |
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