Anti-CD7 Antibody-Cytokine Fusion Protein, scFv (scFv3A1F)-sFasL
CAT#: ACFP-SH121
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD7 scFv to sFasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD7 as well as the biological activity of sFasL. The soluble protein was inactive and required binding to tumor cells expressing CD7 to induce a tumoricidal activity for the treatment of T-cell leukemia. The immunocytokine was applied to eliminate pathogenic synovial fluid Th1 and Treg cells from rheumatoid arthritis and juvenile idiopathic arthritis, thus expanding a possible therapeutic application to chronic inflammatory diseases. This immunocytokine was designed for treating chronic inflammatory diseases.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_A_8_3.jpg
Normal Tissue
Figure 2 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Hep G2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173762-CD7
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Specifications
- Target
- CD7
- Molecule Class
- scFv-sFasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- scFv3A1F
- Related Disease
- Chronic inflammatory diseases
- Cytokine 1
- sFasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
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