Afuco™ Anti-Human CD70 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-130CL
Anti-CD70 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Anti-CD70 ADCC Enhanced Antibody is a CD70-specific antibody that potently modulates both known functions of CD70: tumor cell proliferation and survival, and tumor immune escape.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Autoimmune Diseases; Cancer; Inflammatory Diseases
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
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Consistent results
We have achieved highly repeatable results with this antibody product. For several of the publications we have worked on, it has proven indispensable.
Outstanding value
For what it is, this antibody product is competitively priced. The quality is comparable to more expensive brands that we have used in the past.
Flexible use
Excellent performance has been demonstrated by this antibody product in a variety of applications, such as immunofluorescence and Western blotting.
Q&As
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Is it possible to freeze-thaw cycles using an aliquot of my antibodies?
A: In fact, maintaining the integrity of the antibody is a common operation that involves aliquoting.
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What happens when an antibody doesn't work the way it should?
A: Verify that everything is stored correctly, review your process, and consider contacting the manufacturer for support.
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In what way can I tell if an antibody is suitable for the species I'm interested in?
A: Go to the product specifications for specifics on species reactivity. Try the manufacturer's test if you're unsure.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# AFC-130CL, RRID: AB_3111275)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC | Anti-Human CD70 Recombinant Antibody (Mb VLVH) | ELISA, FC, WB | Human antibody |
| TAB-337LC | Anti-Human CD70 Recombinant Antibody (Mb VHVL) | ELISA, FC, WB | Human antibody |
| TAB-338LC | Anti-Human CD70 Recombinant Antibody (VL-5-VH) | FC, WB | Human antibody |
| TAB-339LC | Anti-Human CD70 Recombinant Antibody (VH-5-VL) | FC, WB | Human antibody |
| TAB-340LC | Anti-Human CD70 Recombinant Antibody (VL-8-VH) | FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
| HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| HPAB-0097-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| HPAB-0099-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0099-LSX) | ELISA, FC, Block | Human IgG |
| HPAB-0100-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0100-LSX) | ELISA, Inhib, ADCC, ADCP, CDC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0095-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0096-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0096-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0097-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0097-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0098-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0098-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0099-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0099-LSX-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H76) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0472-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0472-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC123 | Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced | ELISA, Inhib, ADCC, ADCP, CDC | Antibody hexamer |
| VS-0924-YC124 | Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced | FC, ADCC, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY69 | CytoStream™ Rat Anti-CD70 Recombinant Antibody (clone FR70) | FC, Block, IF, Inhib | Rat IgG2b, kappa |
| VS-0225-XY70 | CytoStream™ Mouse Anti-CD70 Recombinant Antibody (clone Ki-24) | FC | Mouse IgG3, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY72 | Human Anti-CD70 (clone 2H5) scFv-Fc Chimera | FC, ELISA, IHC, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC77 | Recombinant Anti-CD70 Vesicular Antibody, EV Displayed (VS-0425-YC77) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1215 | Anti-CD70 Immunohistochemistry Kit | IHC |
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