Anti-CD70 Antibody-Cytokine Fusion Protein, IgG (c1F6)-IFNγ (CAT#: ACFP-SH160)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD70 IgG to IFNγ. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD70 as well as the biological activity of IFNγ. The immunocytokine displays high levels of species-specific IFN-γ activity and selective binding to CD70 on human RCC cells. This immunocytokine was designed for treating Metastatic renal cell carcinoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
RNA Expression

Specifications

  • Target
  • CD70
  • Molecule Class
  • L Kappa; IgG1-IFNγ
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • c1F6
  • Related Disease
  • Metastatic renal cell carcinoma
  • Cytokine 1
  • IFNγ
  • Cytokines 1 Description
  • Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class ofinterferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily; member 7

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Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-404CQ Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) Block, FC, Inhib, IP Rat IgG2

Recombinant Antibody

CAT Product Name Application Type
HPAB-0095-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) ELISA, FC, ADCC, FuncS Human IgG
HPAB-0096-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) ELISA, FC, Block, FuncS Human IgG
HPAB-0097-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX) ELISA, FC, Block, FuncS Human IgG
HPAB-0099-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0099-LSX) ELISA, FC, Block Human IgG
HPAB-0100-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0100-LSX) ELISA, Inhib, ADCC, ADCP, CDC, FuncS Human IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H76 Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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