Humanized Anti-CD79B Recombinant Antibody (clone Polatuzumab) (CAT#: TAB-897)
This product is a humanized (from mouse) IgG1, κ antibody that can recognize human CD79B.
Specific Inquiry
Cyt
Figure 1 Shows endogenous B cell killing with anti-CD79b/CD3 TDB (T cell dependent bispecific) antibodies produced in either K&H format or as bisfabs (various anti- CD79b clones paired with anti-CD3 clone UCHT1 v9)
Cyt
Figure 2 Shows B cell killing and T cell activation activity of bisfab anti- CD79b/CD3 (CD79b.A7/UCHT1 v9).
FC
Figure 3 Shows monovalent or bivalent binding affinity of various clones of anti- CD79b measured by FACS.
FC
Figure 4 FACS measures the binding affinity of various clones of anti-CD79b.
Bivalent binding affinity of anti-CD79b clones CD79b.F6 and CD79b.A7 comparing to monovalent binding of anti-CD79b clones CD79b.F6, CD79b.A7, and SN8v28 (as bisfab or K&H TDBs).
IHC
Figure 5 CD79B expression in DLBCL.
Immunohistochemical staining of a CD79B-positive DLBCL case with strong CD79B expression (H-score 300; case: DLBCL_63).
Pfeifer, M., Zheng, B., Erdmann, T., Koeppen, H., McCord, R., Grau, M., ... & Dörken, B. (2015). Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes. Leukemia, 29(7), 1578-1586.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- Humanized (from mouse) IgG1, κ
- Specificity
- Human CD79B
- Species Reactivity
- Human
- Clone
- Polatuzumab
- Applications
- Neut, ELISA, IF, IP, FuncS, FC, ICC
Product Property
- Purification
- Protein A/G Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Neutralization, Enzyme-linked Immunosorbent Assay, Immunofluorescence, Immunoprecipitation, Functional Assay, Flow Cytometry, Immunocytochemistry.
Target
- Alternative Names
- B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; CD79b antigen (immunoglobulin-associated beta); CD79b molecule, immunoglobulin-associated beta; Ig-beta; immunoglobulin-associated B29 protein
- Gene ID
- 974
- UniProt ID
- P40259
Related Resources
Please refer to Polatuzumab Vedotin Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Polatuzumab Vedotin.
BCR Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0581 | Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
-
Affordably Priced for Quality
Quality meets the expectation without breaking the bank. Good value for the price. -
Reproducible Across Multiple Hosts
Tested secondary antibodies from different suppliers and found it universally compatible, maintaining specificity. -
Fast Delivery and Responsive Support
Shipped quickly, and customer support was immediately available to answer my storage buffer questions.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-897, RRID: AB_3112017)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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