Mouse Anti-CEA Recombinant Antibody (clone T84.66) (CAT#: PABL-038)

Recombinant Mouse Antibody (T84.66) is capable of binding to CEA, expressed in Chinese Hamster Ovary cells (CHO).


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 ELISA measurements of FcγR binding to scFv-Fc variants.

Figure 1 ELISA measurements of FcγR binding to scFv-Fc variants.

Bind-ing of mFcγRI to titratedamounts of T84.66 and the scFv-Fc variants (WT, I253A, H310A, and H435Q). The numbers given represent the mean of triplicates.

Andersen, J. T., Foss, S., Kenanova, V. E., Olafsen, T., Leikfoss, I. S., Roopenian, D. C., ... & Sandlie, I. (2012). Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. Journal of Biological Chemistry, 287(27), 22927-22937.

FuncS

Figure 2 SPR analyses of the interaction of chimeric anti-CEA T84.66 IgG1 with mFcRn and hFcRn.

Figure 2 SPR analyses of the interaction of chimeric anti-CEA T84.66 IgG1 with mFcRn and hFcRn.

Representative sensorgrams show serial dilutions of anti-CEA T84.66 IgG1(0.004-1μM) injected over a flow cell coupledwith mFcRn (~300 RU) at a flow rate of 50␮l/min (pH6.0).

Andersen, J. T., Foss, S., Kenanova, V. E., Olafsen, T., Leikfoss, I. S., Roopenian, D. C., ... & Sandlie, I. (2012). Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. Journal of Biological Chemistry, 287(27), 22927-22937.


Specifications

  • Immunogen
  • Human Carcinoembryonic Antigen
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human CEA
  • Species Reactivity
  • Human
  • Clone
  • T84.66
  • Applications
  • ELISA, WB, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Function Assay.

Target

  • Alternative Names
  • CEA; Carcinoembryonic Antigen

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone T84.66"

See other products for "CEA"

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for PABL-038. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare