Recombinant Human Anti-CHIKV E2 Antibody (PABL-430) (CAT#: PABL-430)
Recombinant Human Antibody is capable of binding to CHIKV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CHIKV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CHIKV E2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody bound to CHIKV E2 B domain provided an explanation for its neutralizing activity. Binding to the B domain was associated with repositioning of the A domain of E2 that enabled cross-linking of neighboring spikes.
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Specifications
- Immunogen
- Chikungunya virus E2 glycoprotein
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native CHIKV E2
- Species Reactivity
- CHIKV
- Applications
- IB, ELISA, BL
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Immunoblotting, Enzyme-Linked Immunosorbent Assay and Blocking.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibodies
Fab Antibodies
ScFv Antibodies
Mouse Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-431 | Recombinant Mouse Anti-CHIKV E2 Antibody (CHK9) | Neut, BL | IgG |
| MOB-152CQ | Mouse Anti-CHIKV E2 Antibody (CHK265) | Neut, ELISA, IF, FC | Mouse IgG1, λ |
| HPAB-S0184-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152) | Neut, FRNT, FuncS | Human IgG |
| HPAB-S0185-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152 N297Q) | Neut, FRNT, FuncS | Human IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Suitable for Serum-Free Assays;
The antibody performed as expected even after multiple freeze-thaw cycles. Very comforting for extended trials.
Stable During Repeated Freeze-Thaws;
When this was used in co-immunoprecipitation, the target protein was effectively brought down. Extremely satisfied with its binding power.
Effective for Studies on Protein-Protein Interactions
functions well in media without serum, preserving specific binding and lowering background.
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For Research Use Only. Not For Clinical Use.
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