Recombinant Mouse Anti-CHIKV E2 Antibody (CHK9) (CAT#: PABL-431)

Recombinant Mouse Antibody (CHK9) is capable of binding to CHIKV E2 , expressed in Chinese Hamster Ovary cells (CHO). This antibody neutralize CHIKV infectivity by blocking the cellular binding site on the A domain of E2 and inhibits fusion by stabilizing domain B of E2, preventing exposure of the fusion loop on E1.


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Figure 1 Neutralizing activity of CHK-9 intact MAb and Fab fragment against CHIKV.

Figure 1 Neutralizing activity of CHK-9 intact MAb and Fab fragment against CHIKV.

MAbs and Fab fragments were mixed with 100 FFU of infectious CHIKV (strain La Reunion 2006 OPY-1) for one hour at 37°C before infecting Vero cells. Each data point is the average of three independent experiments performed in triplicate. Error bars represent standard deviations.

Sun, S., Xiang, Y., Akahata, W., Holdaway, H., Pal, P., Zhang, X., ... & Rossmann, M. G. (2013). Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. Elife, 2, e00435.


Specifications

  • Immunogen
  • Chikungunya virus E2 glycoprotein
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native CHIKV E2
  • Species Reactivity
  • CHIKV
  • Clone
  • CHK9
  • Applications
  • Neut Assay-depended
    BL Assay-depended

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • Assay-depended

Target

  • Alternative Names
  • E2; E2 glycoprotein; CHIKV; chikungunya virus

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone CHK9"

See other products for "CHIKV E2"

Recombinant Antibody

Mouse Antibody

CAT Product Name Application Type
MRO-1158LC Anti-CHIKV E2 Recombinant Antibody (3C3) ELISA, WB, IF, FC Mouse Antibody
MRO-1159LC Anti-CHIKV E2 Recombinant Antibody (3E4) ELISA, WB, IF, FC Mouse Antibody
MRO-1160LC Anti-CHIKV E2 Recombinant Antibody (8A4) ELISA, WB, IF, FC Mouse Antibody
MRO-1158LC-F(E) Anti-CHIKV E2 Recombinant Antibody Fab Fragment (3C3) ELISA, WB, IF Mouse Antibody
MRO-1159LC-F(E) Anti-CHIKV E2 Recombinant Antibody Fab Fragment (3E4) ELISA, WB, IF Mouse Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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