Recombinant Mouse Anti-CHIKV E2 Antibody (CHK9) (CAT#: PABL-431)
Recombinant Mouse Antibody (CHK9) is capable of binding to CHIKV E2 , expressed in Chinese Hamster Ovary cells (CHO). This antibody neutralize CHIKV infectivity by blocking the cellular binding site on the A domain of E2 and inhibits fusion by stabilizing domain B of E2, preventing exposure of the fusion loop on E1.
Specific Inquiry
Figure 1 Neutralizing activity of CHK-9 intact MAb and Fab fragment against CHIKV.
MAbs and Fab fragments were mixed with 100 FFU of infectious CHIKV (strain La Reunion 2006 OPY-1) for one hour at 37°C before infecting Vero cells. Each data point is the average of three independent experiments performed in triplicate. Error bars represent standard deviations.
Sun, S., Xiang, Y., Akahata, W., Holdaway, H., Pal, P., Zhang, X., ... & Rossmann, M. G. (2013). Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. Elife, 2, e00435.
Specifications
- Immunogen
- Chikungunya virus E2 glycoprotein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native CHIKV E2
- Species Reactivity
- CHIKV
- Clone
- CHK9
- Applications
- Neut Assay-depended
BL Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-430 | Recombinant Human Anti-CHIKV E2 Antibody (PABL-430) | IB, ELISA, BL | IgG |
| MOB-152CQ | Mouse Anti-CHIKV E2 Antibody (CHK265) | Neut, ELISA, IF, FC | Mouse IgG1, λ |
| HPAB-S0184-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152) | Neut, FRNT, FuncS | Human IgG |
| HPAB-S0185-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152 N297Q) | Neut, FRNT, FuncS | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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