Anti-Human CXCR4 Recombinant Antibody (6C7) (CAT#: TAB-154MZ)
This antibody that specifically binds to CXCR4 and inhibits the biological activity of CXCR4 may be useful for diagnostics and treatment of diseases associated with the activity and expression of CXCR4.
Specific Inquiry
Inhib
Figure 1 shows line graphs representing dose-response curves for various antibodies in inhibition of Jurkat cell chemotaxis.
Inhib
Figure 2 depicts inhibitory activity of antibody 6C7 in U937 (2A) and HSC-F (2B) chemotaxis assays.
Block
Figure 3 shows the results demonstrating blocking of labeled SDF-1 binding to Namalwa cells by antibody 6C7.
Block
Figure 4 provides line graphs depicting Kinexa analysis of on-cell affinity of antibodies to human CXCR4 on Namalwa cells.
FuncS
Figure 5 is a bar chart shows induction of apoptosis by various antibodies in Ramos cells.
FuncS
Figure 6 depicts the results of experiments evaluating the activity of an anti-CXCR4 antibody of the disclosure in a model of ovarian cancer.
FuncS
Figure 7 depicts the results of experiments evaluating the effects of an anti-CXCR4 antibody of the disclosure in a chronic lymphocytic leukemia (CLL) model.
Specifications
- Immunogen
- Chinese Hamster Ovary (CHO) cells transiently transfected with human CXCR4
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Cynomolgus
- Clone
- 6C7
- Applications
- Block, FuncS, Inhib
- Related Disease
- CXCR4 mediated diseases such as CXCR4 positive tumors
Applications
- Application Notes
- This antibody has been reported for use in Blocking, Functional Assay, Inhibition.
Target
- Alternative Names
- CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor
- Gene ID
- 7852
- UniProt ID
- P61073
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0314CL | Mouse Anti-CXCR4 Recombinant Antibody (TAB-0314CL) | FC | Mouse IgG |
| TAB-0314CL-S(P) | Mouse Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-0314CL-S(P)) | FC | Mouse scFv |
| TAB-143MZ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-143MZ-F(E)) | cAMP Assay | Mouse Fab |
| TAB-144MZ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-144MZ-F(E)) | cAMP Assay | Mouse Fab |
| TAB-145MZ-F(E) | Mouse Anti-CXCR4 Recombinant Antibody; Fab Fragment (TAB-145MZ-F(E)) | cAMP Assay | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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