anti-DBH immunotoxin 4F10.2 (IgG)-Sap
CAT#: AGTO-L010S
This immunotoxin was achieved by conjugating/fusing the Anti-DBH monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neuronal cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of neuroblastoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5960/1669_D6_1_selected.jpg
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- L kappa; IgG1-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Neuroblastoma
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "DBH"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2334z | Mouse Anti-DBH Recombinant Antibody (clone 25D3) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MOB-0592CT | Recombinant Mouse anti-Rat DBH Monoclonal antibody (9.G.405) | ELISA, ICC, RID, WB | |
| VS3-FY2194 | Rabbit Anti-DBH Recombinant Antibody (clone R48-3P-5) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1908 | Anti-DBH Immunohistochemistry Kit | IHC |
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