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anti-DBH immunotoxin 4F10.2 (IgG)-Sap (AGTO-L010S)

This immunotoxin was achieved by conjugating/fusing the Anti-DBH monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neuronal cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of neuroblastoma.      

  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
L kappa; IgG1-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Neuroblastoma
Target
Alternative Names
DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase); DBM; dopamine beta-hydroxylase; Neuroblastoma; saporin; saporin-6; saporin-S6
Entrez Gene ID
1621
UniProt ID
P09172

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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