Recombinant Mouse Anti-DENV Antibody (E111) (CAT#: PABX-054)

Figure 1 Kinetic analysis of E111 interaction with DENV genotypes and single variants.

SPR traces are presented of E111 MAb interacting with 16007 DIII.

Austin, S. K., Dowd, K. A., Shrestha, B., Nelson, C. A., Edeling, M. A., Johnson, S., ... & Fremont, D. H. (2012). Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope. PLoS pathogens, 8(10), e1002930.

Figure 2 E111 neutralization of different DENV-1 genotypes is only partially dependent on differences in epitope sequence.

E111 were incubated with wild type or V345A West Pac-74 RVPs for one hour at 37°C, and then added to Raji-DC-SIGNR cells. Infection was assessed by flow cytometry 48 hours later. One representative experiment of four is shown. The data is normalized relative to the infectivity of the RVPs in the absence of antibody. Error bars indicate standard error of the mean of replicate infections.

Austin, S. K., Dowd, K. A., Shrestha, B., Nelson, C. A., Edeling, M. A., Johnson, S., ... & Fremont, D. H. (2012). Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope. PLoS pathogens, 8(10), e1002930.