Recombinant Mouse Anti-DENV EDIII Antibody (2H12)
CAT#: PABL-437
Recombinant Mouse Antibody (2H12) is capable of binding to DENV EDIII , expressed in Chinese Hamster Ovary cells (CHO). This antibody is cross-reactive to all four serotypes in the dengue virus group. Crystal structures of 2H12 in complex with domain III of the envelope protein from three dengue serotypes have been determined.
Published Data
Figure 1 ELISA analysis of binding profile for soluble EDIII or rsDIIIs against mAb 2H12.
Half maximal effective concentration (EC50) values for 232 WT DENV-2 EDIII against 2H12 was 0.017nM.
Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O., Dowd, K. A., Pierson, T. C., ... & Lai, J. R. (2018). Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice. Journal of virology, 92(18), e01023-18.
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native DENV EDIII
- Species Reactivity
- DENV
- Clone
- 2H12
- Applications
- ELISA 1:1000-1:20000
Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Dengue virus; DENV; dengue virus E-DIII; DENV E-DIII
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Q&As
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What is the best way to ensure the antibody's stability over time?
A: Store antibodies properly, minimize exposure to light and temperature fluctuations, and avoid repeated freeze-thaw cycles by aliquoting the antibody solution.
-
How do I select an appropriate secondary antibody for my experiment?
A: Choose a secondary antibody that is specific to the host species and isotope of your primary antibody, and choose a detection method compatible with your assay needs.
-
Can this antibody handle high levels of stress during sample preparation?
A: While the antibody is robust, extreme conditions such as high heat or strongly acidic/basic environments should be avoided during sample preparation.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 2H12"
- CAT
- Product Name
See other products for "DENV E-DIII"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-275 | Recombinant Anti-DENV E-DIII Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-275 | Recombinant Human Anti-DENV E-DIII Antibody | ELISA, WB, FC, FuncS | IgG |
| PABC-031 | Recombinant Mouse Anti-DENV E-DIII Antibody (1A1D-2) | WB, ELISA | IgG |
| MRO-1612CQ | Recombinant Human Anti-DENV E-DIII Antibody (DV10) | ELISA, Neut | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-275-F(E) | Recombinant Anti-DENV E-DIII Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| MHH-275-F(E) | Recombinant Human Anti-DENV E-DIII Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
| PFBC-031 | Recombinant Mouse Anti-DENV E-DIII Antibody Fab Fragment (1A1D-2) | WB, ELISA | IgG |
| PFBL-434 | Recombinant Mouse Anti-DENV EDIII Antibody Fab Fragment (2H12) | ELISA, Neut | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-275-S(P) | Recombinant Anti-DENV E-DIII Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| MHH-275-S(P) | Recombinant Human Anti-DENV E-DIII Antibody scFv Fragment | Neut, IF, FuncS | scFv |
| PSBC-031 | Recombinant Mouse Anti-DENV E-DIII Antibody scFv Fragment (1A1D-2) | WB, ELISA | scFv |
| PSBL-434 | Recombinant Mouse Anti-DENV EDIII Antibody scFv Fragment (2H12) | ELISA, Neut | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-044 | Recombinant Mouse Anti-DENV Antibody (3E31) | WB, ELISA, FuncS, Neut, Inhibt | IgG |
| PABX-045 | Recombinant Mouse Anti-DENV Antibody (PABX-045) | WB, ELISA, FuncS, IF | IgG |
| PABX-054 | Recombinant Mouse Anti-DENV Antibody (E111) | WB, ELISA, FuncS, SPR, Neut | IgG |
| PABX-044-S (P) | Recombinant Mouse Anti-DENV Antibody scFv Fragment (3E31) | WB, ELISA, FuncS | scFv |
| PABX-044-F (E) | Recombinant Mouse Anti-DENV Antibody Fab Fragment (3E31) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-054-S (P) | Recombinant Mouse Anti-DENV Antibody scFv Fragment (E111) | WB, ELISA, FuncS | scFv |
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