Recombinant Mouse Anti-DENV EDIII Antibody (2H12) (CAT#: PABL-437)
Recombinant Mouse Antibody (2H12) is capable of binding to DENV EDIII , expressed in Chinese Hamster Ovary cells (CHO). This antibody is cross-reactive to all four serotypes in the dengue virus group. Crystal structures of 2H12 in complex with domain III of the envelope protein from three dengue serotypes have been determined.
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Figure 1 ELISA analysis of binding profile for soluble EDIII or rsDIIIs against mAb 2H12.
Half maximal effective concentration (EC50) values for 232 WT DENV-2 EDIII against 2H12 was 0.017nM.
Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O., Dowd, K. A., Pierson, T. C., ... & Lai, J. R. (2018). Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice. Journal of virology, 92(18), e01023-18.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native DENV EDIII
- Species Reactivity
- DENV
- Clone
- 2H12
- Applications
- ELISA 1:1000-1:20000
Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Dengue virus; DENV; dengue virus E-DIII; DENV E-DIII
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-275 | Recombinant Anti-DENV E-DIII Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-275 | Recombinant Human Anti-DENV E-DIII Antibody | ELISA, WB, FC, FuncS | IgG |
| PABC-031 | Recombinant Mouse Anti-DENV E-DIII Antibody (1A1D-2) | WB, ELISA | IgG |
| MRO-1612CQ | Recombinant Human Anti-DENV E-DIII Antibody (DV10) | ELISA, Neut | Human antibody |
Customer Reviews and Q&As
Customer Review
Q&As
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The antibody was provided promptly and efficiently. I was able to use it in my research without delay, and the device performed as intended.
Positive Replications
I've repeated my studies several times with this antibody and have consistently gotten reliable findings. It has become an essential component of my research workflow.
Detailed Product Information
The product website contained detailed information about the antibody, making it simple to grasp its applications and performance expectations. I am quite delighted with my buy.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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