Recombinant Mouse Anti-DENV EDIII Antibody (2H12) (CAT#: PABL-437)

Recombinant Mouse Antibody (2H12) is capable of binding to DENV EDIII , expressed in Chinese Hamster Ovary cells (CHO). This antibody is cross-reactive to all four serotypes in the dengue virus group. Crystal structures of 2H12 in complex with domain III of the envelope protein from three dengue serotypes have been determined.


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Figure 1 ELISA analysis of binding profile for soluble EDIII or rsDIIIs against mAb 2H12.

Figure 1 ELISA analysis of binding profile for soluble EDIII or rsDIIIs against mAb 2H12.

Half maximal effective concentration (EC50) values for 232 WT DENV-2 EDIII against 2H12 was 0.017nM.

Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O., Dowd, K. A., Pierson, T. C., ... & Lai, J. R. (2018). Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice. Journal of virology, 92(18), e01023-18.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native DENV EDIII
  • Species Reactivity
  • DENV
  • Clone
  • 2H12
  • Applications
  • ELISA 1:1000-1:20000
    Neut Assay-depended

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • Assay-depended

Target

  • Alternative Names
  • Dengue virus; DENV; dengue virus E-DIII; DENV E-DIII

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 2H12"

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Recombinant Antibody

Human Antibody

CAT Product Name Application Type
PABX-054-S (P) Recombinant Mouse Anti-DENV Antibody scFv Fragment (E111) WB, ELISA, FuncS scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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