Anti-DENV1 E Recombinant Antibody (3H12) (CAT#: MRO-1093LC)
3H12 was reactive with all DENV types, and cross-reacted with these viruses, such as Japanese encephalitis and West Nile viruses. MAb 3H12 exhibited only enhancing activities, which were suppressed by pretreatment of cells with anti-FcγRIIa. Induction of 3H12 in Mochizuki-immunized mice may have implications for dengue vaccine strategies designed to minimize induction of enhancing antibodies in vaccinated humans.
Specific Inquiry
Neut
Figure 1 Neutralizing and enhancing activities of DENV-1 MAbs.
Balance between neutralizing and enhancing activities of five DENV-1 MAbs obtained in our assay system using semiadherent K562 cells. C(+), presence of complement; C(−), absence of complement; Ave, average.
A Mouse Monoclonal Antibody against Dengue Virus Type 1 Mochizuki Strain Targeting Envelope Protein Domain II and Displaying Strongly Neutralizing but Not Enhancing Activity
Neut
Figure 2 Effect of the IgG subclass or epitope site on the balance of neutralizing activity and enhancing activity.
The balances were compared among four antibodies of different IgG subclasses (IgG1, IgG2a, IgG2b, and IgG3) engineered from 7F4 (closed circles) or 3H12 (open circles) in the absence.
A Mouse Monoclonal Antibody against Dengue Virus Type 1 Mochizuki Strain Targeting Envelope Protein Domain II and Displaying Strongly Neutralizing but Not Enhancing Activity
Specifications
- Immunogen
- A DNA vaccine expressing premembrane and E proteins of DENV-1
- Host Species
- Mouse
- Type
- Mouse Antibody
- Specificity
- Dengue virus-1
- Clone
- 3H12
- Applications
- ELISA, Neut
- Related Disease
- Dengue virus-1 infection
Applications
- Application Notes
- In the antibody-dependent enhancement (ADE) assay, the infection rate of U937 cells with this antibody in the absence of complement was 91%. It is positively reacted with DENV-1 to DENV-4 in ELISA assay.
Target
- Alternative Names
- Dengue virus-1; DENV1; Dengue virus-1 envelope protein E; DENV1 E
- Gene ID
- 5075725
- UniProt ID
- P17763
- Long Name
- Dengue virus-1 envelope protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1088LC-S(P) | Anti-DENV1 E Recombinant Antibody scFv Fragment (15C12) | ELISA | Mouse Antibody |
| MRO-1089LC-S(P) | Anti-DENV1 E Recombinant Antibody scFv Fragment (9B1) | ELISA | Mouse Antibody |
| MRO-1090LC-S(P) | Anti-DENV1 E Recombinant Antibody scFv Fragment (8F6) | ELISA | Mouse Antibody |
| MRO-1091LC-S(P) | Anti-DENV1 E Recombinant Antibody scFv Fragment (3C9) | ELISA | Mouse Antibody |
| MRO-1092LC-S(P) | Anti-DENV1 E Recombinant Antibody scFv Fragment (7F4) | ELISA | Mouse Antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1104LC-F(E) | Human Anti-DENV1 E Recombinant Antibody; Fab Fragment (MRO-1104LC-F(E)) | ELISA | Human Fab |
| MRO-1105LC-F(E) | Human Anti-DENV1 E Recombinant Antibody; Fab Fragment (MRO-1105LC-F(E)) | ELISA | Human Fab |
| MRO-1111LC-F(E) | Human Anti-DENV1 E Recombinant Antibody; Fab Fragment (MRO-1111LC-F(E)) | ELISA | Human Fab |
| MRO-1112LC-F(E) | Human Anti-DENV1 E Recombinant Antibody; Fab Fragment (MRO-1112LC-F(E)) | ELISA | Human Fab |
| MRO-1123LC-F(E) | Human Anti-DENV1 E Recombinant Antibody; Fab Fragment (MRO-1123LC-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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