Anti-Human DKK1 Recombinant Antibody (RH2-80)
CAT#: TAB-201MZ
The human anti-Dkk-1 antibody RH2-80 was prepared using the human single chain Fv phage display library. RH2-80 is specific for Dkk-1. The epitope maps primarily to within cysteine-rich-domain-2 of Dkk-1. RH2-80 can be potentially used as an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway for treating bone disorders which results in a loss in bone, for example, osteoporosis.
Published Data
Gene Expression
Inhib
Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.
FuncS
Figure 2 shows the transcriptional effects of RH2-80 antibodies (Dkk-IAB) on cultured cancer cells in a TOPflash transcription assay performed in HCTl 16 cells in complete medium. 8B4 was the control non-specific antibody. Con was vehicle control.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
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Specifications
- Host Species
- Human
- Derivation
- Human phage display library
- Type
- Human antibody
- Specificity
- Human
- Clone
- RH2-80
- Applications
- FuncS, Inhib
- Related Disease
- A loss in bone, such as osteoporosis
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1882z | Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0096-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-0096-FY) | FuncS | Human IgG, κ |
| HPAB-0107-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-0107-FY) | FuncS | Human IgG, λ |
| VS-0723-WK25 | Human Anti-DKK1 Recombinant Antibody (clone Sirexatamab) | FC | Human IgG4 |
| VS-0723-WK110 | Rabbit Anti-DKK1 Recombinant Antibody (VS-0723-WK110) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-192MZ-S(P) | Anti-Mouse DKK1 Recombinant Antibody scFv Fragment (JC18) | ELISA | |
| TAB-194MZ-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-194MZ-S(P)) | ELISA | Mouse scFv |
| TAB-196MZ-S(P) | Rat Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-196MZ-S(P)) | ELISA | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195MZ-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-195MZ-S(P)) | In vivo efficacy assay | Human scFv |
| TAB-197MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH1-10) | WB | Human antibody |
| TAB-198MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-18) | WB | Human antibody |
| TAB-199MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-31) | WB | Human antibody |
| TAB-200MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-59) | WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
| TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) | ELISA | Single domain antibody |
| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
| TAB-013MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-013MZ-VHH) | ELISA | Single domain antibody |
| HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| MOR-4137 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) | ELISA, Block, FuncS | Human scFv |
| HPAB-0279-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) | Block, FuncS | Human scFv |
| HPAB-0280-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) | ELISA | Human scFv |
| HPAB-670-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) | ELISA | Human scFv |
| HPAB-0757-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0757-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) | FuncS | Human Fab |
| HPAB-0107-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0107-FY-F(E)) | FuncS | Human Fab |
| HPAB-0757-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0757-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0758-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0758-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0759-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0759-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2001 | Anti-DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2002 | Anti-Mouse DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2003 | Anti-Human DKK1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC46 | Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80) | Inhib | Tandem scFv |
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