Afuco™ Anti-Human DLL4 ADCC Recombinant Antibody (MEDI0639), ADCC Enhanced (CAT#: AFC-205CL)

Anti-DLL4 ADCC Enhanced Antibody (MEDI0639) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI0639 is an investigational monoclonal antibody that selectively binds to Delta-like ligand 4 (DLL4) and blocks its ability to bind to and activate signaling through the Notch receptors, potentially inhibiting tumor growth by multiple mechanisms. Of 20 safety-evaluable pts, the most common treatment-related adverse events (trAEs) were increased aspartate aminotransferase, increased brain natriuretic peptide (BNP), and fatigue. No treatment-related deaths occurred. MEDI0639 150 mg did not exceed the MTD. Enrollment at the 200 mg dose level is ongoing. The safety profile is consistent with the mechanism of action and appears to be manageable. Preliminary evidence of antitumor activity was observed.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Solid Tumors

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.

Target

  • Alternative Names
  • DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "DLL4"

Humanized Antibody

CAT Product Name Application Type
TAB-204 Anti-Human DLL4 Recombinant Antibody (Demcizumab) ELISA, FC, IP, FuncS, IF, Neut, WB IgG2 - kappa

Rat Antibody

CAT Product Name Application Type
TAB-217CL Human Anti-DLL4 Recombinant Antibody (TAB-217CL) WB, IHC, IF, FC, Inhib Human IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-707CQ Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2) Block Hamster IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4140 Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS) ELISA Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0203-CN Human Anti-DLL4 Recombinant Antibody (HPAB-0203-CN) ELISA, WB, FC, IP Human IgG1
HPAB-0204-CN Human Anti-DLL4 Recombinant Antibody (HPAB-0204-CN) ELISA, WB, FC, IP Human IgG1
HPAB-0205-CN Human Anti-DLL4 Recombinant Antibody (HPAB-0205-CN) ELISA, WB, FC, IP Human IgG4
HPAB-0206-CN Mouse Anti-DLL4 Recombinant Antibody (HPAB-0206-CN) ELISA, WB, FC, IHC, IF, ICC Mouse IgG2
HPAB-0208-CN Human Anti-DLL4 Recombinant Antibody (HPAB-0208-CN) ELISA, WB, FC, IHC, IF, ICC Humanized IgG2

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-204 Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Single-domain Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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