Anti-DNA Antibody-Cytokine Fusion Protein, IgG (chTNT-3)-IFNγ
CAT#: ACFP-SH138
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-DNA IgG to IFNγ. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the DNA as well as the biological activity of IFNγ. The chTNT3/muIFN-γ can safely target syngeneic tumor models as part of a promising strategy for the targeted immunotherapy of solid tumors. This immunocytokine was designed for treating tumor.
Specifications
- Target
- DNA
- Molecule Class
- IgG-IFNγ
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- chTNT-3
- Related Disease
- Tumor
- Cytokine 1
- IFNγ
- Cytokines 1 Description
- Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class ofinterferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Deoxyribonucleic acid; ss DNA
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