Anti-DNA Antibody-Cytokine Fusion Protein, IgG (chTNT-3)-IL12 (CAT#: ACFP-SH139)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-DNA IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the DNA as well as the biological activity of IL12. The activity of the expressed chTNT-3/huIL12 was confirmed by standard IL12 bioactivity assays which demonstrated that the fusion protein induced similar levels of peripheral blood lymphocyte (PBL) proliferation as free recombinant IL12. This immunocytokine was designed for treating tumor.

Specific Inquiry
  • Size:

  • Conjugation:

  • Datasheet
  • MSDS
  • COA

Specifications

  • Target
  • DNA
  • Molecule Class
  • IgG-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • chTNT-3
  • Related Disease
  • Tumor
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • Deoxyribonucleic acid; ss DNA

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone chTNT-3"

See other products for "DNA"

Select a product category from the dropdown menu below to view related products.
Please select product type
Fab Antibody Products Mouse Antibody Products Humanized Antibody Products IgG Antibody Products ScFv Antibody Products IgM Antibody Products Autoantibody Products ScFv-Fc Chimera Products

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for ACFP-SH139. Click the button above to contact us or submit your feedback about this product.

Popular products with customers


For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare