Mouse Anti-DNA Recombinant Antibody (clone A52) (CAT#: PABL-451)
Recombinant Mouse Antibody (A52) is capable of binding to DNA, expressed in Chinese Hamster Ovary cells (CHO).
Specific Inquiry
ELISA
Figure 1 Reactivity of anti-DNA mAbs with dsDNA anda-actinin in ELISA.
Binding assay of anti-dsDNA antibodies A52 and D42 to dsDNA demonstrates that both antibodies bound to dsDNA.
Mjelle, J. E., Rekvig, O. P., Van Der Vlag, J., & Fenton, K. A. (2011). Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens. Autoimmunity, 44(5), 373-383.
FuncS
Figure 2 The anti-α-actinin and anti-DNA antibodies do not co-localise in nephritic kidneys from F1 mice.
IEM demonstrating binding of experimental anti-DNA antibodies A52 detected by RaM IgG followed by PAG10 on sections from a nephritic kidney from a 29 w.o F1 mouse with glomerulonephritis class IV.
Mjelle, J. E., Rekvig, O. P., Van Der Vlag, J., & Fenton, K. A. (2011). Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens. Autoimmunity, 44(5), 373-383.
Specifications
- Immunogen
- Deoxyribonucleic acid
- Host Species
- Mouse
- Type
- Mouse IgG
- Clone
- A52
- Applications
- ELISA, WB, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Function Assay.
Target
- Alternative Names
- Deoxyribonucleic acid; DNA
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
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Autoantibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-048 | Recombinant Mouse Anti-DNA Antibody | WB, ELISA, FuncS | IgG |
| PABX-048-F (E) | Recombinant Mouse Anti-DNA Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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