Recombinant Anti-HCV E2 VHH Single Domain Antibody (PNBL-019)
CAT#: PNBL-019
Anti-HCV E2 VHH Single Domain Antibody is a recombinant protein produced in E. coli.
Published Data
Figure 3 Genotype 1 clones show both resistant and sensitive phenotypes.
HCVpp supplemented with genotypes were neutralized by increasing concentrations of mAb nB D03 and the resulting infectivity plotted against antibody concentration.
Urbanowicz, R. A., McClure, C. P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., ... & Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of virology, 90(7), 3288-3301.
Figure 4 Normally distributed IC50 values for each antibody.
Frequency distribution plots of log10 IC50 values, and the derived Gaussian curve, from all 81 clones for mAb D03. Mean log10 IC50 value for each antibody is represented by a red dashed line, mean ± 2 standard deviations by a solid red line and mean ± 3 standard deviations by the grey fill. Each plot fitted a normal distribution curve as shown by the D'Agostino & Pearson omnibus normality test.
Urbanowicz, R. A., McClure, C. P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., ... & Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of virology, 90(7), 3288-3301.
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Specifications
- Immunogen
- HCV E2 envelope protein
- Host Species
- Llama
- Derivation
- Llama
- Type
- Llama VHH
- Species Reactivity
- HCV
- Clone
- PNBL-019
- Applications
- Functional Assay, Inhibition
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody was validated for Functional Assay, Inhibition. For details, refer to Published Data.
Target
- Alternative Names
- E2; HCV; envelope protein; hepatitis C virus
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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