Recombinant Anti-HCV E2 VHH Single Domain Antibody (PNBL-019) (CAT#: PNBL-019)
Anti-HCV E2 VHH Single Domain Antibody is a recombinant protein produced in E. coli.
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Figure 3 Genotype 1 clones show both resistant and sensitive phenotypes.
HCVpp supplemented with genotypes were neutralized by increasing concentrations of mAb nB D03 and the resulting infectivity plotted against antibody concentration.
Urbanowicz, R. A., McClure, C. P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., ... & Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of virology, 90(7), 3288-3301.
Figure 4 Normally distributed IC50 values for each antibody.
Frequency distribution plots of log10 IC50 values, and the derived Gaussian curve, from all 81 clones for mAb D03. Mean log10 IC50 value for each antibody is represented by a red dashed line, mean ± 2 standard deviations by a solid red line and mean ± 3 standard deviations by the grey fill. Each plot fitted a normal distribution curve as shown by the D'Agostino & Pearson omnibus normality test.
Urbanowicz, R. A., McClure, C. P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., ... & Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of virology, 90(7), 3288-3301.
Specifications
- Immunogen
- HCV E2 envelope protein
- Host Species
- Llama
- Derivation
- Llama
- Type
- Llama VHH
- Species Reactivity
- HCV
- Clone
- PNBL-019
- Applications
- Functional Assay, Inhibition
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody was validated for Functional Assay, Inhibition. For details, refer to Published Data.
Target
- Alternative Names
- E2; HCV; envelope protein; hepatitis C virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-040 | Recombinant Mouse Anti-CHIKV E2 glycoprotein Antibody (PABL-040) | IF, Neut, IP | IgG |
| PABL-357 | Recombinant Human Anti-VEEV E2 Antibody (F5) | WB, ELISA, Neut, FuncS | IgG |
| PABZ-180 | Recombinant Mouse Anti-HCV E2 Antibody (mAb#8) | Neut | IgG |
| PABZ-181 | Recombinant Human Anti-HCV E2 Antibody (hu5B3.v3) | ELISA, Neut | IgG |
| PABC-184 | Recombinant Chimeric (Human/Mouse) Anti-HCV glycoprotein E2 Antibody (mAb1:7) | Neut | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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