Recombinant Human Anti-EBOV GP Antibody (KZ52 )
CAT#: PABL-458
Recombinant Human Antibody (KZ52 ) is capable of binding to EBOV GP, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-EBOV GP mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-EBOV GP proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Published Data
Figure 1 Reactivity of human anti-Ebola virus Fab KZ52 with a γ-irradiated whole-virion preparation (open squares) and with irradiated crude infected-cell supernatants (solid circles) determined by ELISA.
Ovalbumin (4 μg/ml) is included as a control antigen (open diamonds). OD405, optical density at 405 nm.
Maruyama, T., Rodriguez, L. L., Jahrling, P. B., Sanchez, A., Khan, A. S., Nichol, S. T., ... & Burton, D. R. (1999). Ebola virus can be effectively neutralized by antibody produced in natural human infection. Journal of virology, 73(7), 6024-6030.
Figure 2 Reactivity of anti-Ebola virus Fabs with live and fixed Ebola virus-infected Vero E6 cells shown by immunofluorescence.
Staining is shown for Fab KZ52 on live (A) and fixed (D) Ebola virus-infected cells, for Fab LZ51 on live (B) and fixed (E) Ebola virus-infected cells, and for ELZ510 on live (C) and fixed (F) Ebola virus-infected cells.
Maruyama, T., Rodriguez, L. L., Jahrling, P. B., Sanchez, A., Khan, A. S., Nichol, S. T., ... & Burton, D. R. (1999). Ebola virus can be effectively neutralized by antibody produced in natural human infection. Journal of virology, 73(7), 6024-6030.
Figure 3 Longer-exposure autoradiograms obtained to reveal the immunoprecipitation of Fab KZ52 to GP2.
Exposure of autoradiograms for 2.5 months (compared to 1 week for panel B) reveals immunoprecipitation of a band corresponding to GP2 by Fab KZ52 from Ebola virus-infected cell supernatants (lanes 1) and from crude infected-cell supernatants (lanes 2). Lanes 3 is uninfected-cell supernatant controls.
Maruyama, T., Rodriguez, L. L., Jahrling, P. B., Sanchez, A., Khan, A. S., Nichol, S. T., ... & Burton, D. R. (1999). Ebola virus can be effectively neutralized by antibody produced in natural human infection. Journal of virology, 73(7), 6024-6030.
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Specifications
- Immunogen
- EBOV spike glycoprotein
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native EBOV GP
- Species Reactivity
- EBOV
- Clone
- KZ52
- Applications
- Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
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(Creative Biolabs Cat# PABL-458, RRID: AB_3714181)
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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