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    Anti-EDB Antibody-Cytokine Fusion Protein, IgG-IL12 (CAT#: ACFP-SH086)

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to the N-terminus of the IL12 p35 subunit, which in turn is disulfide-bonded to the p40 subunit.. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. This protein has been shown to have a longer serum half-life than antibody-muIL12 in mice, and retains both antigen binding and IL12 activity in in vitro assays. This molecule also was found to have surprisingly low toxicity in immunocompetent mice. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Endothelial cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Hepatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
    Figure 4 Testis
    Figure 4 Testis
    (Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
    Figure 5 Placenta
    Figure 5 Placenta
    (Decidual cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Trophoblastic cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
    Figure 6 Lymph node
    Figure 6 Lymph node
    (Germinal center cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
    RNA Expression
    Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
    Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1

    Specifications

    • Target
    • EDB
    • Molecule Class
    • IgG1-IL12
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • HuBC1
    • Related Disease
    • Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
    • Cytokine 1
    • IL12
    • Cytokines 1 Description
    • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
    • Cytokine 1 Species
    • Mouse
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

    Related Resources

    • Related Diseases

    Downloads

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