Anti-EDB Antibody-Cytokine Fusion Protein, IgG-scIL12 (CAT#: ACFP-SH014)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of scIL12. Antitumor activity of this fusion protein involved a combination of T and NK cell activity, a switch to a Th1 immune response, and an anti-angiogenic activity. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.

Specific Inquiry
  • Size:

  • Conjugation:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • EDB
  • Molecule Class
  • IgG3-scIL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • AS1409
  • Related Disease
  • HER-2/neu over-expressing cancer
  • Cytokine 1
  • scIL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Related Resources

  • Related Diseases

Downloads

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