This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of GM-CSF. The immunocytokine L19-GM-CSF was expressed in mammalian cells and purified to homogeneity, revealing no loss of cytokine activity in in vitro assays. L19-GM-CSF displayed a potent antitumor activity both in s.c. and in metastatic F9 and C51 murine models of cancer in immunocompetent mice. For L19-GM-CSF immunocytokine, CD8+ T cells seemed to mostly contribute to the therapeutic action as shown by in vivo cell depletion experiments. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-193 | Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | [(scFv - heavy - kappa) - IGHE - CH4]2 |
TAB-001CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
TAB-002CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (ME-4C) | ELISA, IHC | Human antibody |
TAB-003CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (1C5) | ELISA, WB | Human antibody |
TAB-004CQ-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (TAB-004CQ-S(P)) | ELISA, IHC, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0105YC | Human Anti-FN1 Recombinant Antibody (clone ME4C) | ELISA, IHC | Human IgG |
MRO-0589-CN | Rabbit Anti-FN1 Recombinant Antibody (clone JF0582) | WB, IF, IHC | Rabbit IgG |
HPAB-1110-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1110-FY) | IHC | Human IgG |
HPAB-1111-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1111-FY) | IHC | Human IgG |
HPAB-1112-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1112-FY) | IHC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
HPAB-1111-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1111-FY-S(P)) | IHC | Human scFv |
HPAB-1112-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1112-FY-S(P)) | IHC | Human scFv |
HPAB-S0037-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); Fab Fragment | ELISA, IB, IHC | Human Fab |
HPAB-S0038-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone L19); Fab Fragment | ELISA, IF, IHC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1705-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02610); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-1706-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02611); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-1707-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02613); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-S0037-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment | ELISA, IB, IHC | Human scFv |
HPAB-S0038-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment | ELISA, IF, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) | ELISA, In vivo imaging | Camelid VHH |
There are currently no Customer reviews or questions for ACFP-SH091. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.