Anti-EDB Antibody-Cytokine Fusion Protein, scIL12-scFv (L19)-TNFα (CAT#: ACFP-SH187)

• Target
• EDB

• Molecule Class
• scIL12-scFv-TNFα

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• L19

• Related Disease
• Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma

• Cytokine 1
• TNFα

• Cytokines 1 Description
• Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

• Cytokine 1 Species
• Human

• Cytokine 2
• IL12

• Cytokines 2 Description
• Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.

• Cytokine 2 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Alternative Names
• FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

• Gene ID
• 2335

• UniProt ID
• P02751

• ACFP-SH164
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