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    Mouse Anti-EDN1 Recombinant Antibody (clone TR.ET.48.5) (CAT#: NEUT-717CQ)

    This antibody is a mouse monoclonal antibody that binds specifically to Endothelin 1, and it can neutralize the bioactivity of Endothelin 1.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/if_selected.jpg
    Figure 2 IHC staining of human colon
    Figure 2 IHC staining of human colon
    (Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells and endothelial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/66918_A_9_3_selected.jpg
    Figure 3 IHC staining of human colon
    Figure 3 IHC staining of human colon
    (Immunohistochemical staining of human colon shows plasma positivity in blood vessels.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_3_selected.jpg
    Figure 4 IF staining of human cell line U-2 OS
    Figure 4 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/321_D9_7_blue_red_green.jpg
    Figure 5 IF staining of human cell line U-251 MG
    Figure 5 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/323_D9_1_blue_red_green.jpg
    Normal Tissue
    Figure 6 Lung
    Figure 6 Lung
    (Alveolar cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Macrophages
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_1_4.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_3.jpg
    Figure 8 Liver
    Figure 8 Liver
    (Hepatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_4.jpg
    Figure 9 Kidney
    Figure 9 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_9_5.jpg
    Figure 10 Testis
    Figure 10 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Leydig cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_6_6.jpg
    RNA Expression
    Figure 11 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, T-47d, TIME)
    Figure 11 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, T-47d, TIME)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000078401-EDN1

    Specifications

    • Immunogen
    • The immunogen corresponding to a region within amino acids 60 and 68 of human ET-1
    • Host Species
    • Mouse
    • Type
    • Mouse IgG1
    • Specificity
    • Human EDN1
    • Species Reactivity
    • Human, Mouse, Canine, Porcine, Rat, Rabbit, Sheep
    • Clone
    • TR.ET.48.5
    • Applications
    • Block, ELISA, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, RIA, WB
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Purified with affinity chromatography
    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • EDN1; endothelin 1; ET1; QME; PPET1; ARCND3; HDLCQ7

    Related Resources

    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "EDN1"

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    NAB-818-VHH Recombinant Anti-Human EDN1 VHH Single Domain Antibody FA, FC, ICC, ELISA Llama VHH

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